中国药科大学药学院导师：杨勇 正文

　　杨勇，男，1976年12月生，博士、副教授。2000年获得临床医学学士学位，2005年获得药理学博士学位，主要从事基于转化医学的分子靶向抗肿瘤药物研究与开发。2009年入选教育部“新世纪优秀人才计划”，并被选为江苏省“333高层次人才培养工程”中青年科学技术带头人和江苏省“六大人才高峰”高层次人才。在国际权威学术期刊如 JBC、CDD、Carcinogenesis、Molecular Cancer Therapy等累计发表SCI论文30余篇，累积影响因子超过100分，研究成果得到国际学术界的高度认可，被Cancer research，Blood等多篇国际著名杂志引用。一篇SCI论文入选科技部中国科学技术信息研究所评出的“2008年中国百篇最具影响国际学术论文”。
　　2011年作为项目负责人承担国家自然科学基金重大研究计划1项，国家自然科学基金面上项目2项；承担科技部“十二五重大新药创制专项”1项；承担江苏省自然科学基金2项。2005年获得“江苏省科技进步一等奖”和“中华医学三等奖”，2007年荣获“江苏省科技进步二等奖”。兼任国家自然科学基金评审专家、研究生教材《肿瘤药理学》副主编、全国高等医药院校药学类统编教材编委和Cancer research等多个国际学术期刊的特约审稿人。

　　近年来发表的论文：
　　1. Zhang WB, Wang Z, , , , , *. Activation of AMP-activated protein kinase by temozolomide contributes to apoptosis in glioblastoma cells via p53 activation and mTORC1 inhibition. 2010, 285, 52: 40461–40471.（Corresponding author）
　　s of histone deacetylase inhibitors via AKT de-phosphorylation and α-tubulin hyper-acetylation both in vitro and in vivo. Cell Death & Disease. (2011) 2, e117; doi:10.1038/cddis.2010.96. （Corresponding author）
　　3. Yong Yang, Lin-bo Zhang, Lei Qiang, Qing Zhao, Yan-jun Ma, Zhi-yu Li, Qi-Dong You, Qing-Long Guo. Wogonin induced calreticulin/Annexin A1 exposure dictates the immunogenicity of cancer cells in a PERK/AKT dependent manner. PLoS ONE. 2011，revised.
　　4. Chen Fei-Hong; Zhang Lin-Bo; Qiang Lei; Yang Zhen; Wu Tian; Zou Mei-Juan; Tao Lei; You Qi-Dong; Li Zhi-Yu; Yang Yong*; Guo Qing-Long. Reactive oxygen species-mitochondria pathway involved in LY-202-induced apoptosis in human hepatocellular carcinoma HepG(2) cells. Cancer letters.2010;296(1):96-105. (Corresponding author）
　　5. Lei Qiang, Yong Yang, Qi-Dong You, Yan-Jun Ma, et al. Inhibition of glioblastoma growth and angiogenesis by gambogic acid: an in vitro and in vivo study. Biochemical Pharmacology. 2008, 75(5):1083-92.（Co-first author）
　　6. Qiang L, Yang Y, You QD, Ma YJ, et al. Isolation and characterization of cancer stem like cells in human glioblastoma cell lines. Cancer letters. 2009， 279(1):13-21. （Co-first author）
　　7. Gambogic acid induced G2/M phase cell cycle arrest via disturbing CDK7 mediated phosphorylation of CDC2/P34 in human gastric carcinoma BGC-823 cells. Carcinogenesis. 2007, 28(3)632-8.
　　8. Yong Yang, Lan Yang, Qi-Dong You, Fei-Fei Nie, Hong-Yan Gu, Li Zhao, Xiao-Tang Wang, Qing-Long Guo. Differential apoptotic induction of gambogic acid, a novel anticancer natural product, on hepatoma cells and normal hepatocytes. Cancer Letters. 2007, 256:259-26.
　　9. Yong Yang, Yang Hu, Hong-Yan Gu, Na Lu, et al. Oroxylin A induces G2/M phase cell-cycle arrest via inhibiting Cdk7-mediated expression of Cdc2/p34 in human gastric carcinoma BGC-823 cells. Journal of Pharmacy and Pharmacology. 2008, 60(11):1459-63.
　　10. Na Lu, Yong Yang, Qi-Dong You, Yun Ling, Ying Gao, Hong-Yan Gu, Li Zhao, Xiao-Tang Wang, Qing-Long Guo.Gambogic Acid Inhibits angiogenesis through suppressing vascular endothelial growth factor -induced tyrosine phosphorylation of KDR/Flk-1. Cancer Letters. 2007. 258(1):80-9. （Co-first author）
　　11. Qing Zhao, Yong Yang, Jun Yu, Qi-Dong You, Shi Zeng, Hong-Yan Gu, Na Lu, Qi Qi, Wei Liu, Xiao-Tang Wang, Qing-Long Guo. Posttranscriptional Regulation of the Telomerase hTERT by Gambogic Acid in Human Gastric Carcinoma 823 Cells. Cancer letters. 2008, 262(2):223-31.（Co-first author）
　　12. Yun Ling, Yong Yang, Na Lu, Qi-dong You, Sen Wang,Ying Gao, Yan Chen, Qing-Long Guo. Endostar, a novel recombinant human endostatin, exerts antiangiogenic effect via blocking VEGF-induced tyrosine phosphorylation of KDR/Flk-1 of endothelial cells. Biochemical and Biophysical Research Communications. 2007. 361:79-84. (Corresponding author）
　　13. . Endostar suppresses invasion through down-regulating the expression of matrix metalloproteinase-2/9 in MDA-MB-435 human breast cancer cells Experimental Biology and Medicine.2008, 233(8):1013-20.. （Corresponding author）
　　14. Hai-Wei Zhang, Yong Yang, Kun Zhang, Lei Qiang, Li Yang, Lan Yang, Yang Hu, Xiao-Tang Wang, Qi-Dong You, Qing-Long Guo. Wogonin Induced Differentiation and G1 Phase Arrest of Human U-937 Leukemia Cells via PKCδ Phosphorylation. European Journal of Pharmacology. 2008, 591(1-3):7-12.  （Co-first author）
　　15. , , , , , , , , , , , , , . Gambogic acid mediates apoptosis as a p53 inducer through down-regulation of mdm2 in wild-type p53-expressing cancer cells. 2008, 7(10):3298-305.
　　16. Hao Li, Qiu-Juan Wang, Dan-Ni Zhu and Yong Yang. Reinioside C, a Triterpene Saponin of Polygala aureocauda Dunn, exerts Hypolipidemic Effect on Hyperlipidemic Mice. Phytother Res. 2008; 22(2):159-64. （Corresponding author）
　　17. Zhang, Kun; You, Qidong; Yang, Yong; Zhang, Haiwei; Yang, Li; Gu, Hongyan; Qi, Qi; Tan, Zi; Wang, Xiaotang; Guo, Qinglong. Wogonin induces the granulocytic differentiation of human NB4 promyelocytic leukemia cells and up-regulates phospholipid scramblase 1 gene expression. Cancer Science. 2008, 99(4):689-95.
　　18. Qi, Qi; Gu, Hongyan; You, Qidong; Yang, Yong; et al. Involvement of matrix metalloproteinase 2 and 9 in gambogic acid induced suppression of MDA-MB-435 human breast carcinoma cell lung  metastasis. Journal of Molecular and Medicine. 2008, 86(12):1367-77.
　　19. Qi Q, Lu N, Wang XT, Gu HY, Yang Y, Liu W, Li C, You QD, Guo QL. Anti-invasive effect of gambogic acid in MDA-MB-231 human breast carcinoma cells. Biochem Cell Biol. 2008, 86(5):386-95.
　　20. Lu N, Gao Y, Ling Y, Chen Y, Yang Y, Gu HY, Qi Q, Liu W, Wang XT, You QD, Guo QL. Wogonin suppresses tumor growth in vivo and VEGF-induced angiogenesis through inhibiting tyrosine phosphorylation of VEGFR2. Life Sciences. 2008 23;82(17-18):956-63.
　　21. Microtubule depolymerization and phosphorylation of c-Jun N-terminal kinase-1 and p38 were involved in gambogic acid induced cell cycle arrest and apoptosis in human breast carcinoma MCF-7 cells. Life Sciences. 2008;83(3-4):103-9.
　　22. Gambogic acid induced tumor cell apoptosis by T lymphocyte activation in H(22) transplanted mice. Int Immunopharmacol. 2008, 8(11):1493-502.
　　23. Inhibition of alpha(4) integrin mediated adhesion was involved in the reduction of B16-F10 melanoma cells lung colonization in C57BL/6 mice treated with Gambogic acid. Eur J Pharmacol. 2008, 589(1-3):127-31.
　　24. . Endostar suppresses invasion through down-regulating the expression of matrix metalloproteinase-2/9 in MDA-MB-435 human breast cancer cells Experimental Biology and Medicine.2008, revised. （Corresponding author）
　　25. Gambogic acid induced G2/M phase cell cycle arrest via disturbing CDK7 mediated phosphorylation of CDC2/P34 in human gastric carcinoma BGC-823 cells. Carcinogenesis. 2007,28(3)632-8.
　　26. Qinglong Guo, Li Zhao, Yong Yang，Hongyan Gu, Guoliang Song, Na Lu, Jian Xin , Qidong You. Anti-hepatitis B virus activity of wogonin in vitro and in vivo. Antiviral Research .2007, 74(1)16-24.
　　27. Yang Hu, Yong Yang, Qi-Dong You, Wei Liu, Hong-Yan Gu, Li Zhao ,Kun Zhang, Wei Wang, Xiao-Tang Wang, Qing-Long Guo. Oroxylin A induced apoptosis of human hepatocellular carcinoma cell line HepG2 was involved in its antitumor activity. Biochemical and Biophysical Research Communications 351 (2006) 521–527. （Co-first author）
　　28. Wang W, Guo QL, You QD, Zhang K, Yang Y, Yu J, Liu W, Zhao L, Gu HY, Hu Y, Tan Z, Wang XT. The Anticancer Activities of Wogonin in Murine Sarcoma S180 both in Vitro and in Vivo. Biol Pharm Bull. 2006;29(6):1132-7.
　　29. Wang W, Guo Q, You Q, Zhang K, Yang Y, Yu J, Liu W, Zhao L, Gu H, Hu Y, Tan Z, Wang X. Involvement of bax/bcl-2 in wogonin-induced apoptosis of human hepatoma cell line SMMC-7721.Anticancer Drugs. 2006 17(7):797-805.
　　30. Yong Yang, Xing Liu, Yan Long, Fang Wang, Jian-Hua Ding, Su-Yi Liu, Ye-Hong Sun, Hong-Hong Yao, Hai Wang, Jie Wu, Gang Hu. Activation of mitochondrial ATP-sensitive potassium channels improves rotenone-related motor and neurochemical alterations in rats. The International Journal of Neuropsycopharmacology, 2006;9 (1):51-61.
　　31. Hua CHEN, Yong YANG, Hong-hong YAO, Xing-chun TANG, Jian-hua DING, Hai WANG, Gang HU. Protective effects of iptakalim, a novel ATP-sensitive potassium channel opener, on global cerebral ischemia-evoked insult in gerbil. Acta Pharmacol Sin 2006, 27(6):665-72. （Co-first author）
　　32. Liu X, Wu JY, Zhou F, Sun XL, Yao HH, Yang Y, Ding JH, Hu G. The regulation of rotenone-induced inflammatory factor production by ATP-sensitive potassium channel expressed in BV-2 cells. Neuroscience Letters, 2006; 394(2):131-5.
　　33. Yong Yang, Xing Liu, Yan Long, Fang Wang, Jian-Hua Ding, Su-Yi Liu, Ye-Hong Sun, Hong-Hong Yao, Hai Wang, Jie Wu, Gang Hu. Systemic administration of iptakalim, a novel ATP-sensitive potassium channel opener, prevents rotenone-induced motor and neurochemical alterations in rats. Journal of Neuroscience Research, 2005; 80 (3): 442-449.
　　34. Yang Y, Liu X, Ding JH, Long Y, Wang F, Yao HH, Hu G. Effects of iptakalim on rotenone-induced cytotoxicity and dopamine release from PC12 cells. Neuroscience Letters, 2004; 366 (1), 53-57.
　　35. Sen Wang, Li-fang Hu, Yong Yang, Jian-hua Ding, Gang Hu. Studies of ATP-sensitive potassium channels on 6-hydroxydopamine and haloperidol rat models of Parkinson’s disease: Implications for treating Parkinson’s disease? Neuropharmacology, 2005; 48 (7): 984-992.

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