Nmae：蔡辉, Ph.D, M.D.

Institute： 1．School of public Health, Nantong University

2．Vanderbilt Epidemiology Center, Institute for Medicine & Public Health

Vanderbilt University Medical Center

Address： Sixth Floor, Suite 600, 2525 West End Avenue, Nashville, TN 37203

Phone： +1-615-936-3468 (Work), +1-615-309-7618(Home)

Email： hui.cai@vanderbilt.edu

EDUCATION

2002-2005 Post-doctoral training in Epidemiology．Vanderbilt University, Nashville, TN.

Major： Biostatistics and Molecular Epidemiology.

1992-1995 Ph.D., West China University of Medical Sciences, Chengdu, Sichuan, China.

Major： Medical and Health Statistics

Three-year training program for Doctoral Degree (Ph.D.) in Medical and Health Statistics.

Research Subject： Evaluation theory, method and application used in Medicine and Health Management.

Dissertation： Statistical theory and methods in Comprehensive evaluation.

1984-1987 M.S., China Medical University, Shenyang, Liaoning, China．

Major： Medical Statistics and Epidemiology

Research Subject： Multivariable Statistical Methods and Application.

Dissertation： The Principle and Method of the Constellation Graph and its Application in Medicine.

1977-1982 M.D., Nantong Medical College, Nantong, Jiangsu, China.

Major： Medicine

研究方向：

1． Biostatistical method in the epidemiological stusy

2． Cancer Research： Genetic and environmental factors and their interaction

3． Association of chronic disease and nutrition

主持在研项目：

1．Cell Cycle/Apoptosis Gene Variants and Breast Cancer Risk RO1(CA122756)

To evaluate whether genetic polymorphisms in cell cycle/apoptosis pathways may be associated with the risk of breast cancer.

2．Breast Cancer Survival： Lifestyle and Genetic Determinants(Shanghai Breast Cancer Survival Study) RO1(CA118229)

To investigate the role of diet and genetic polymorphisms of genes involving tumor microenvironment on breast cancer prognosis．

完成项目：

1．“Genetic Consequences of Therapies for Cancer” (RO1 CA104666)

2．“.Soyfood, Gene Polymorphisms and Risk of Endometrial Cancer” (RO1CA92585)

近五年发表论文：

1．Cai H, Xiang YB, Qu S, Long J, Cai Q, Gao J, et al． Association of genetic polymorphisms in cell-cycle control genes and susceptibility to endometrial cancer among chinese women． Am J Epidemiol．2011; 11(173)：1263-71.

2． Villegas R, Xiang YB, Cai H, Elasy T, Cai Q, Zhang X, et al． Lifestyle determinants of c-reactive protein in middle-aged, urban Chinese men． Nutr Metab Cardiovasc Dis．2010 Nov 24．[Epub ahead of print].

3． Wu X, Cai H, Xiang YB, Cai Q, Yang G, Liu D, et al．Intra-person variation of urinary biomarkers of oxidative stress and inflammation．Cancer Epidemiol Biomarkers Prev．2010;19(4)：947-52.

4． Villegas R, Yang G, Gao YT, Cai H, Li H, Zheng W, et al．Dietary patterns are associated with lower incidence of type 2 diabetes in middle-aged women： the Shanghai Women's Health Study． Int J Epidemiol．2010 Jun;39(3)：889-99.

5． Shu XO, Zheng Y, Cai H, Gu K, Chen Z, Zheng W, et al．Soy Food Intake and Breast Cancer Survival．JAMA．2009; 302： 2437-43．PMCID： PMC2874068.

6． Lee SA, Cai H, Yang G, Xu WH, Zheng W, Li H, et al． Dietary patterns and blood pressure among middle-aged and elderly Chinese men in Shanghai． Br J Nutr 2010; 2(104)：265-75.

7． Lu W, Cui Y, Chen X, Zheng Y, Gu K, Cai H, et al．Changes in quality of life among breast cancer patients three years post-diagnosis．Breast Cancer Res Treat．2009 Mar; 114(2)：357-69．Epub 2008 Apr 14．PMID： 18409069

8． Beeghly-Fadiel A, Shu XO, Long J, Li C, Cai Q, Cai H, et al．Genetic polymorphisms in the MMP-7 gene and breast cancer survival．Int J Cancer．2009 Jan 1; 124(1)：208-14．PMCID： PMC2597698.

9． Cai H, Shu XO, Egan KM, Cai Q, Long JR, Gao YT, Zheng W．Association of Genetic polymorphisms in CYP19A1 and blood levels of sex hormones among postmenopausal Chinese women．Pharmacogenet Genomics．2008; 18： 657-64.

10．Qu S, Long J, Cai Q, Shu XO, Cai H, Gao YT, et al．Genetic polymorphisms of metastasis suppressor gene NME1 and breast cancer survival．Clin Cancer Res． 2008 Aug 1; 14(15)：4787-93．PMCID： PMC2713865.

11． Long JR, Cai Q, Shu XO, Cai H, Gao YT, Zheng W．Genetic polymorphisms in estrogen-metabolizing genes and breast cancer survival．Pharmacogenet Genomics．2007 May; 17(5)：331-8．PMID： 17429315.

12．Cai H, Zheng W, Xiang YB, Xu WH, Yang G, Li HL, et al．Dietary patterns and their correlates among middle-aged and elderly Chinese men： a report from the Shanghai Men’s Health study．Br J Nutr．2007; 98：1006-13.

13． Long JR, Cai Q, Shu XO, Cai H, Gao YT, Zheng W．Genetic polymorphisms in estrogen-metabolizing genes and breast cancer survival． Pharmacogenet Genomics．2007 May;17(5)：331-8.

14．Lu W, Cui Y, Zheng Y, Gu K, Cai H, Li Q, et al．Impact of newly diagnosed breast cancer on quality of life among Chinese women．Breast Cancer Res Treat．2007 Apr;102(2)：201-10．Epub 2006 Jul 19．PMID： 16850242.

15． Zhang X, Shu XO, Yang G, Li H, Cai H, Gao YT, et al．Abdominal adiposity and mortality in Chinese women．Arch Intern Med．2007 May 14; 167(9)：886-92．PMID： 17502529.

16．Cai H, Shu XO, Gao YT, Li H, Yang G, Zheng W．A prospective study of dietary patterns and mortality in Chinese women．Epidemiology．2007 May; 18(3)：393-401．PMID： 17435450.

17．Cui Y, Shu XO, Gao YT, Cai H, Tao MH, Zheng W．Association of ginseng use with survival and quality of life among breast cancer patients．Am J Epidemiol．2006 Apr 1; 163(7)：645-53．Epub 2006 Feb 16．

18．Qi Z, Cai H, Morrow JD, Breyer MD．Differentiation of cyclooxygenase 1- and 2-derived prostanoids in mouse kidney and aorta．Hypertension．2006 Aug;48(2)：323-8．

19．Shrubsole MJ, Shu XO, Ruan ZX, Cai Q, Cai H, Niu Q, et al．MTHFR genotypes and breast cancer survival after surgery and chemotherapy： a report from the Shanghai Breast Cancer Study．Breast Cancer Res Treat．2005 May; 91(1)：73-9．

20．Cai H, Shu XO, Hebert JR, Jin F, Yang G, Liu DK, Gao YT, Zheng W．Variation in nutrient intakes among women in Shanghai, China．Eur J Clin Nutr．2004;58(12)：1604-11.

荣誉获奖：

1．‘Excellent course, first prize for Health Statistics’, awarded by the Department of Education, Jiangsu．I taught the course of “Health Statistics” 2000．

2．‘Study of evaluating method and index system for hospital benefit’, received the award as the Outstanding Contribution Award in National Health Economics from Society for Chinese Health Economics．2000.

3．‘Study of evaluating method and index system for hospital benefit’, received advancing science and technology award from Jiangsu, China．1999.

4．‘Comprehensive benefit evaluation among health units in Nantong’, received advancing science and technology award of government from Nantong, China． 1999.

5．Outstanding scholar of “333 project” in Jiangsu Province, China．1999.

6．Academic Advancer of Affiliated Universities, the Ministry of Communication, China．1999

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