高永静 ，神经生物学专业博士，硕士研究生导师，教授，航海医学研究所副所长，江苏特聘教授。1995年毕业于南通医学院临床医学专业，并被免试推荐为人体解剖学专业硕士研究生（导师：凌树才教授，现工作于浙江大学医学院），1999年获硕士学位。2004年获得复旦大学神经生物学博士学位（导师：赵志奇教授）。2006年5-12月在美国圣路易斯华盛顿大学医学院进行博士后工作。2007年1月至2010年10月在美国哈佛大学医学院工作。2010年11月回国。近五年来，在SCI收录的期刊上发表论文近30篇，总影响因子140多，发表的论文被SCI收录期刊引用600余次；主持完成国家自然科学基金一项、江苏省高校自然科学研究计划项目一项，参与完成多项国家自然科学基金课题、美国NIH课题。目前主持研究国家自然科学基金面上项目一项、江苏省自然科学基金一项。2004年被评为江苏省“青蓝工程”优秀青年骨干教师；2005年被评为南通大学优秀教育工作者，同年获江苏省科技进步三等奖、南通市科技进步二等奖一项（排名第二）；2009年入选教育部新世纪优秀人才支持计划、2010年获南通市青年科技奖；2011年入选江苏省“333”工程第三层次人才、南通市“226”工程第二层次人才，担任中华医学会疼痛学分会基础组委员会委员、中华医学会航海医学分会青年副主任委员、中国神经科学会感觉和运动分会委员、胶质细胞分会委员、江苏省疼痛学会青年委员。多次参加国家自然科学基金项目青年基金项目和面上项目评审，担任《Pain》、《Glia》、《PLoS One》、《Journal of Neuroinflammation》、《Journal of Pain》、《Anesthesia and Analgesia》等近20种疼痛和神经科学领域国际专业杂志审稿专家。

研究方向：

胶质细胞参与慢性疼痛调节的机制；特殊环境下疼痛的传递和调制。

研究团队：

本课题组成员中有具有博士学位的研究人员3名、具有硕士学位的青年教师4名、硕士研究生7名。课题组成员年富力强，具有团结协作精神和对科研工作的浓厚兴趣，是一个奋发向上、朝气蓬勃的集体。

主要通讯作者和第一作者论文

1． Jie Hui, Zhi-Jun Zhang, Xin Zhang, Yan Shen, Yong-Jing Gao*．Repetitive hyperbaric oxygen treatment attenuates complete Freunds adjuvant-induced pain and reduces glia-mediated neuroinflammation in the spinal cord．Journal of Pain, accepted, 2013

2． Zhi-Jun Zhang, Yu-Lin Dong, Ying Lu, Zhi-Qi Zhao, Yong-Jing Gao*．Chemokine CCL2 and its receptor CCR2 in the medullary dorsal horn are involved in trigeminal neuropathic pain．Journal of Neuroinflammation．2012, July 9, 9:136

3． Zhi-Jun Zhang, Lin-Xia Zhao, De-Li Cao, Xin Zhang, Yong-Jing Gao*, Chunlin Xia． Curcumin inhibits LPS-induced CCL2 expression via JNK pathway in C6 rat astrocytoma cells．Cellular and Molecular Neurobiology．2012 Aug;32(6):1003-1010

4． Feng-Li Chen, Yu-Lin Dong, Zhi-Jun Zhang, De-Li Cao, Jie Xu, Jie Hui, Li Zhu, Yong-Jing Gao*．Activation of astrocytes in the anterior cingulate cortex contributes to the affective component of pain in an inflammatory pain model．Brain Research Bulletin, 2012,4;87(1):60-6

5． Ying Lu, Li Zhu, Yong-Jing Gao*．Pain related aversion induced astrocytes activation and proinflammatory cytokines expression in rat anterior cingulate cortex．Brain Research Bulletin．2011, 84(2):178-82．

6． Yong-Jing Gao* and Ru-Rong Ji*．Light touch induces ERK activation in superficial dorsal horn neurons after inflammation: involvement of spinal astrocytes and JNK signaling in touch-evoked central sensitization and mechanical allodynia．Journal of Neurochemistry．2010, 115(2):505-14．

7． Yong-Jing Gao*, -activated astrocytesaLing Zhang, Ru-Rong Ji*．Spinal injection of TNF- produces persistent pain symptom mechanical allodynia by releasing monocyte chemoattractant protein-1 to induce sensitization of dorsal horn neurons．Glia．2010,58(15):1871-80.

8． Yong-Jing Gao*, Ru-Rong Ji*．Targeting Astrocyte Signaling for Chronic Pain Management．Neurotherapeutics．2010, 7(4):482-93

9． Yong-Jing Gao*, Ru-Rong Ji*．Chemokines, neuronal-glial interactions, and central processing of neuropathic pain．Pharmacology and Therapeutics．2010, 126(1):56-68

10．Yong-Jing Gao*, Zhen-Zhong Xu, Yen-Chin Liu, Yeong-Ray Wen, Isabelle Decosterd, Ru-Rong Ji*． The c-Jun N-terminal Kinase 1 (JNK1) in spinal astrocytes mediates bilateral mechanical allodynia under a persistent inflammatory pain condition．Pain, 2010,148:309-319

11．Yong-Jing Gao, Ling Zhang, Omar Abdel Samad, Marc R．Suter, Kawasaki Yasuhiko, Zhen-Zhong Xu, Jong-Yeon Park, Anne-Li Lind, Qiufu Ma, Ru-Rong Ji．JNK-induced MCP-1 production in spinal cord astrocytes contributes to central sensitization and neuropathic pain．Journal of Neuroscience, 2009, 29(13):4096–4108

12．Hong Cao*, Yong-Jing Gao*,Wen-Hua Ren, Ting-Ting Li, Kai-Zheng Duan, Yi-Hui Cui, Xiao-Hua Cao, Zhi-Qi Zhao, Ru-Rong Ji, Yu-Qiu Zhang．Activation of extracellular signal-regulated kinase in the anterior cingulate cortex contributes to the induction and expression of affective pain．Journal of Neuroscience, 2009,29(10):3307–3321 (*Equal contribution)

13．Yong-Jing Gao, Jen-Kun Cheng, Qing Zeng, Zhen-Zhong Xu, Isabelle Decosterd, Xiaoyin Xu, Ru-Rong Ji．Selective inhibition of JNK with a peptide inhibitor attenuates pain hypersensitivity and tumor growth in a mouse skin cancer pain model． Experimental Neurology, 2009, 219:146–155

14．Yong-Jing Gao*, Ru-Rong Ji*．c-Fos or pERK, Which is a better marker for neuronal activation and central sensitization after noxious stimulation and tissue injury? The Open Pain Journal, 2009, 2, 11-17

15．Yong-Jing Gao, Ru-Rong Ji．Activation of JNK pathway in persistent pain．Neuroscience Letter, 2008,6;437(3):180-3

16．Yan-Gang Sun*, Yong-Jing Gao*, Zhong-Qiu Zhao, Bing Huang, Jun Yin, Gregory A Taylor, Zhou-Feng Chen． Involvement of P311 in the affective, but not in the sensory component of pain．Molecular Pain, 2008, 4:23

17．Zhong-Qiu Zhao*, Yong-Jing Gao*, Yan-Gang Sun, Cheng-Shui Zhao, Robert W．Gereau IV, Zhou-Feng Chen．Central serotonergic neurons are differentially required for opioid analgesia, but not for morphine tolerance and morphine reward．PNAS, 2007, 104(36): 14519–14524 (* Equal contribution)

18．Yong-Jing Gao, Wen-Hua Ren, Zhi-Qi Zhao, Yu-Qiu Zhang．Contributions of the anterior cingulate cortex and amygdala to pain- and fear- conditioned place avoidance in rats． Pain, 2004, 110(1-2):343-53

19．Yong-Jing Gao, Yu-Qiu Zhang, Zhi-Qi Zhao．Involvement of spinal neurokinin-1 receptors in the maintenance but not induction of carrageenan-induced thermal hyperalgesia in the rat．Brain Research Bulletin 2003,61(6):587-93

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