温州大学化学与材料工程学院导师：吴华悦 正文

　　姓名：吴华悦　
　　性别：男　
　　出生年月：1962年3月　
　　职称：教授　
　　所在学院：数学与信息科学学院　

　　个人简介
　　吴华悦，男，汉族，1962年3月生，浙江兰溪，中共党员，教授，硕士研究生导师。
　　1984毕业于杭州大学化学系有机化学专业，同年进入温州师范学院任教，现任温州大学有机及药物化学研究所所长，有机化学硕士点负责人，浙江省新药创制平台理事会理事，浙江省新药创制科技服务平台温州工作站负责人。
　　入选温州市“新世纪551人才工程”第一层次、温州大学“高级人才工程”，获温州大学“教坛名师”称号。
　　指导的研究生硕士论文入选2008年度浙江省优秀硕士论文。
　　主持和参加国家“十一五”科技支撑计划项目、国家自然科学基金等国家、省部级科研项目多项，已在Org． Lett．; J． Org． Chem．; Green Chem．; Tetraherdon; Synlett; Tetraherdon Lett．; Synthesis等国内外刊物上发表SCI论文60余篇，申请专利20余项，其中授权发明专利4项。
　　获浙江省科学技术奖2项，目前正从事药物及中间体的合成研究和有机合成方法学研究，是省、市重大科技项目的评审专家。
　　2009年被Encyclopedia of Reagents for Organic Synthesis创刊编辑Leo A． Paquette邀请撰写其中部分章节（Preparation and Application of Tris-1-naphthyl Phosphine），被J． Org． Chem．; Green Chem．和Tetrahedron等期刊选为审稿人。

　　代表论著
　　1．Jiuxi Chen,* Yong Peng, Miaochang Liu, Jinchang Ding, Huayue Wu,* Palladium-catalyzed aerobic oxidative coupling of acyl chlorides with arylboronic acids, Adv． Synth． Catal． 2012 accepted． SCI-TOP
　　2．Quansheng Ding, Jilei Zhang, Jiuxi Chen,* Miaochang Liu, Jinchang Ding, Huayue Wu,* Tandem synthesis of 2,3-dihydroquinazolin-4(1h)-ones on grinding under solvent-free conditions, J． Heterocyclic Chem． 2012, in press． SCI
　　3．Gaigai Liang, Miaochang Liu, Jiuxi Chen,* Jinchang Ding, Wenxia Gao, Huayue Wu,* NBS-promoted sulfenylation of sulfinates with disulfides leading to unsymmetrical or symmetrical thiosulfonates, Chin． J． Chem． 2012, in press． SCI
　　4．Tieqiang Huang, Jinchang Ding, Miaochang Liu, Wenxia Gao, Huayue Wu, Jiuxi Chen,* Catalyst-free protocol for the synthesis of quinoxalines and pyrazines in PEG, J． Heterocyclic Chem． 2012, in press． SCI
　　5．Jilei Zhang, Jiuxi Chen,* Miaochang Liu, Xingwang Zheng, Jinchang Ding, Huayue Wu,* Ligand-free copper-catalyzed coupling of nitroarenes with arylboronic acids, Green Chem． 2012, 14, 912-916． SCI-TOP
　　6．Shaojin Gu, Bo Liu, Jiuxi Chen, Huayue Wu,* Wanzhi Chen,* Synthesis, structures, and properties of ruthenium(II) complexes of N-(1,10-phenanthrolin-2-yl)imidazolylidenes, Dalton Trans． 2012, 41, 962-970． SCI-TOP
　　7．Hui Xu, Wanzhi Chen,* Jiuxi Chen, Huayue Wu,* Stereoselective synthesis of (Z)-1,2-dithio-1-alkenes via copper-catalyzed thiolation of (Z)-2-bromovinyl sulfides, Sythesis 2012, 380–388． SCI-TOP
　　8．Hongjuan Deng, Yujing Fang, Gaowei Chen, Miaochang Liu, Huayue Wu, Jiuxi Chen,* Copper-catalyzed Clauson–Kass pyrroles synthesis in aqueous media, Appl． Organometal． Chem． 2012, 26, 164-167． SCI
　　9．Guowei Kang, Jun Jiang,* Hongxin Liu, Huayue Wu,* Asymmetric organocatalytic synthesis of β-hydroxyynones with a quaternary carbon center under aqueous conditions, J． Braz． Chem． Soc．, 2012, 23, 5-10． SCI
　　10．Xiepeng Lin, Wenxia Gao,* Chenen Li, Jiuxi Chen, Chen Yang, Huayue Wu,* Nano-sized flake carboxymethyl cassava starch as excipient for solid dispersions, Int． J． Pharm． 2012, 423, 435-439． SCI-TOP
　　11．Wei Lu, Jiuxi Chen,* Miaochang Liu, Jinchang Ding, Wenxia Gao, Huayue Wu,* Palladium-catalyzed decarboxylative coupling of isatoic anhydrides with arylboronic acids, Org． Lett． 2011, 13, 6114-6117． SCI-TOP
　　12．Tieqiang Huang, Jun Li, Jiuxi Chen,* Wenxia Gao, Jinchang Ding, Huayue Wu,* Silica sulfuric acid (ssa)/peg as a recyclable system for the synthesis of quinoxalines and pyrazines, Synth． Commun． 2011, 41, 3334–3343． SCI
　　13．Jilei Zhang, Jiuxi Chen,* Jinchang Ding a, Miaochang Liu, Huayue Wu, Copper-catalyzed arylation of indolin-2,3-ones with arylboronic acids, Tetrahedron 2011, 67, 9347-9351． SCI-TOP
　　14．Hanmei Zheng, Jinchang Ding, Jiuxi Chen,* Miaochang Liu, Wenxia Gao, Huayue Wu,* Copper-catalyzed arylation of arylboronic acids with aldehydes, Synlett 2011, 1626-1630． SCI-TOP
　　15．Xingwang Zheng, Jinchang Ding, Jiuxi Chen*, Wenxiao Gao, Miaochang Liu, Huayue Wu,* The coupling of arylboronic acids with nitroarenes catalyzed by rhodium． Org． Lett． 2011, 48, 403-406． SCI-TOP
　　16．Jun Li, Danna Jiang, Jiuxi Chen,* Miaochang Liu, Jinchang Ding, Huayue Wu,* Eco-friendly synthesis of quinoxaline derivatives by grinding under solvent-free conditions． J． Heterocyclic Chem． 2011, 48, 403-406． SCI
　　17．Wenxia Gao, Xiaoqing Lin, Xiepeng Lin, Jinchang Ding, Xiaobo Huang, Huayue Wu,* Preparation of nano-sized flake carboxymethyl cassava starch under ultrasonic irradiation． Carbohydr． Polym． 2011, 84, 1413–1418． SCI
　　18．Yong Peng, Jiuxi Chen,* Jinchang Ding, Miaochang Liu, Wenxiao Gao, Huayue Wu,* Ligand-free copper-catalyzed arylation of olefins by the Mizoroki–Heck reaction． Synthesis 2011, 213-216． SCI-TOP
　　19．Xiepeng Lin, Wenxia Gao*, Xiaobo Huang, Panlong Zang, Jiuxi Chen, Huayue Wu,* Morphology-controlled hollow nanospheres of functionalized dextran by self-assembly in aqueous solution． Carbohydr． Polym． 2010, 82, 460–465． SCI
　　20．Qiang Zhang, Jiuxi Chen,* WenxiaGao, Jinchang Ding, Huayue Wu,* Copper-catalyzed one-pot synthesis of propargylamines via C–H activation in PEG． Appl． Organometal． Chem． 2010, 24, 809-812． SCI
　　21．Weixing Dan, Hongjuan Deng, Jiuxi Chen*, Miaochang Liu, Jinchang Ding, Huayue Wu,* A new odorless one-pot synthesis of thioesters and selenoesters promoted by Rongalite®, Tetrahedron 2010, 66, 7384-7388． SCI-TOP
　　22．Wenxue Guo, Guangshu Lv, Jiuxi Chen*, Wenxia Gao, Jinchang Ding, Huayue Wu,* Rongalite® and base-promoted cleavage of disulfides and subsequent Michael addition to α,β-unsaturated ketones/esters: an odorless synthesis of β-sulfido carbonyl compounds, Tetrahedron 2010, 66, 2297–2300． SCI-TOP
　　23．Xiaoling Xu , Jiuxi Chen*, Wenxia Gao, Huayue Wu,* Jinchang Ding, Weike Su, Palladium-catalyzed hydroarylation of alkynes with arylboronic acids, Tetrahedron 2010, 66,2433–2438． SCI-TOP
　　24．Mingtiao Cai, Guangshu Lv, Jiuxi Chen,* Wenxia Gao, Jinchang Ding, Huayue Wu,* CAN/I2-catalyzed Chemoselective synthesis of thiosulfonates by oxidation of disulfides or thiols, Chem． Lett． 2010, 39, 368-369． SCI
　　25．Shaomiao Lin, Jilei Zhang, Jiuxi Chen,* Wenxia Gao, Jinchang Ding, Weike Su, Huayue Wu,* An Approach to Synthesis of Thioesters and Selenoesters Promoted by Rongalite®, J． Braz． Chem． Soc． 2010, 21, 1616-1620． SCI
　　26．Xiaoliang Yang, Chunmei Xu, Shaomiao Lin, Jiuxi Chen,*, Jinchang Ding, Huayue Wu,* Weike Su, Eco-friendly synthesis of 2-substituted benzothiazoles catalyzed by cetyltrimethyl ammonium bromide (CTAB) in Water, J． Braz． Chem． Soc． 2010, 21, 37-42． SCI
　　27．Shuanghua Cheng, Jiuxi Chen,* Wenxia Gao, Huile Jin, Jinchang Ding, Huayue Wu,* Oxidative esterification of aldehydes with alcohols and phenols in air, J． Chem． Res． 2010, 130-132． SCI
　　28．Yali Xu, Jiuxi Chen, Wenxia Gao, Huile Jin, Jinchang Ding, Huayue Wu,* Solvent-free synthesis of 3,5-di(hetero)aryl-1,2,4-thiadiazoles by grinding of thioamides under oxidative conditions． J． Chem． Res． 2010, 151-153． SCI
　　29．Jiuxi Chen, Changfu Zhang, Wenxia Gao, Huile Jin, Jinchang Ding, Huayue Wu,* B2O3/Al2O3 as a new, highly efficient and reusable heterogeneous catalyst for the selective synthesis of β-enamino ketones and esters under solvent-free conditions, J． Braz． Chem． Soc． 2010, 21, 1552-1556． SCI
　　30．Hanmei Zheng, Qiang Zhang, Jiuxi Chen, Miaochang Liu, Shuanghua Cheng, Jinchang Ding,* Huayue Wu,* Weike Su, Copper(II) acetate-catalyzed addition of arylboronic acids to aromatic aldehydes, J． Org． Chem． 2009, 74, 943-945． SCI-TOP
　　31．Huilong Xiao, Jiuxi Chen, Miaochang Liu, Dongjian Zhu, Jinchang Ding,* Huayue Wu,* Trichloroisocyanuric acid (TCCA) as a mild and efficient catalyst for the synthesis of 2-arylbenzothiazoles, Chem． Lett． 2009, 38, 170-171． SCI
　　32．Bing Zuo, Jiuxi Chen, Miaochang Liu, Huayue Wu,* Weike Su,* Yb(OTf)3-catalyzed synthesis of pyrroles under solvent-free conditions, Chin． Chem． Lett． 2009, 20, 423–426． SCI-E
　　33．Bing Zuo, Jiuxi Chen, Miaochang Liu, Jinchang Ding, Huayue Wu,* Weike Su,* Scandium Triflate-catalysed synthesis of N-substituted pyrroles from amine and 2,5-dimethoxytetrahydrofuran, J． Chem． Res． 2009, 14-16． SCI
　　34．Dongjian Zhu, Jiuxi Chen, Miaochang Liu, Jinchang Ding, Huayue Wu,* Catalyst and solvent-free synthesis of imidazo[1,2-a]pyridines, J． Braz． Chem． Soc． 2009, 20, 482-487． SCI
　　35．Wei Xiong, Jiuxi Chen, Miaochang Liu, Jinchang Ding, Huayue Wu,* Weike Su,* A general and efficient synthesis of pyrazoles catalyzed by Sc(OTf)3 under Solvent-Free Conditions, J． Braz． Chem． Soc． 2009, 20, 367-374． SCI
　　36．Tieqiang Huang, Qaing Zhang, Jiuxi Chen,* Wenxia Gao, Jinchang Ding, Huayue Wu,* Synthesis of quinoxalines catalysed by cetyltrimethyl ammonium bromide (CTAB) in aqueous media, J． Chem． Res． 2009, 761-765． SCI
　　37．Dongjian Zhu, Jiuxi Chen, Dengze Wu, Miaochang Liu, Jinchang Ding, Huayue Wu,* An Efficient, Catalyst- and solvent-free synthesis of imidazo-[1,2-a]pyridines and 2,4-disubstituted thiazoles on grinding, J． Chem． Res． 2009, 84-86． SCI
　　38．Wenxue Guo, Jiuxi Chen*, Dengze Wu, Jinchang Ding, Fan Chen, Huayue Wu,* Rongalite® promoted highly regioselective synthesis of β-hydroxy sulfides by ring opening of epoxides with disulfides, Tetrahedron 2009, 65 , 5240–5243． SCI-TOP
　　39．Dongjian Zhu, Jiuxi Chen, Huilong Xiao, Miaochang Liu, Jinchang Ding, Huayue Wu,* Efficient and expeditious synthesis of di- and trisubstituted thiazoles in PEG under catalyst-free conditions, Synth． Commun． 2009, 39, 2895–2906． SCI
　　40．Jiuxi Chen, Xiaoliang Yang, Miaochang Liu, Huayue Wu,* Jinchang Ding, Weike Su, Approach to synthesis of β-enamino ketones and pyrroles catalyzed by gallium(III) triflate under solvent-free conditions, Synth． Commun． 2009, 39, 4180–4198． SCI
　　41．Qiang Zhang, Chunmei Xu, Jiuxi Chen,* Xiaoling Xu, Jinchang Ding, Huayue Wu,* Palladium-catalyzed arylation of arylglyoxals with arylboronic acids, Appl． Organometal． Chem． 2009, 23, 524–526． SCI
　　42．Wenxue Guo, Huile Jin, Jiuxi Chen,*, Fan Chen, Jinchang Ding, Huayue Wu,* An Efficient Catalyst-Free Protocol for the Synthesis of Quinoxaline Derivatives under Ultrasound Irradiation, J． Braz． Chem． Soc． 2009, 20, 1674-1679． SCI
　　43．Xiaoliang Yang, Yali Xu, Jiuxi Chen*, Jinchang Ding, Huayue Wu,* Weike Su, Sodium dithionite-promoted synthesis of 2-arylbenzothiazoles by reaction of 2,2-disulfanediyldianiline with aldehydes in water, J． Chem． Res． 2009, 682–685． SCI
　　44．Huilong Xiao, Jiuxi Chen, Miaochang Liu, Huayue Wu,* Jinchang Ding, An approach to disulfide synthesis promoted by sulfonyl chloride in sodium bicarbonate aqueous media, Phosphorus, Sulfur, and Silicon, 2009, 184,2553–2559． SCI
　　45．Mingtiao Cai, Jiuxi Chen, Xiaobo Huang, Miaochang Liu, Jinchang Ding,* Huayue Wu,* Synthesis of fluorinated β-carbolines by one-pot reaction, J． Chem． Res． 2008, 296-298． SCI
　　46．Jinchang Ding,* Rong Xu, Miaochang Liu, Xi’an Chen, Huayue Wu,* Gallium triiodide as a highly efficient and mild catalyst for the diethyl acetalization of carbonyl compounds J． Indian Chem． Soc． 2008, 85, 566-568． SCI
　　47．Changming Qin, Huayue Wu,* Jiuxi Chen, Miaochang Liu, Jiang Cheng,* Weike Su, Jinchang Ding, Palladium-catalyzed aromatic esterification of aldehydes with organoboronic acids and molecular oxygen, Org． Lett． 2008, 10, 1537-1540． SCI-TOP
　　48．Qiang Zhang, Jiuxi Chen, Miaochang Liu, Huayue Wu,* Jiang Cheng,* Changming Qin, Weike Su, Jinchang Ding, Palladium-catalyzed addition of arylboronic acids to N-tosylarylimines, Synlett 2008, 935-939． SCI-TOP
　　49．Changming Qin, Jiuxi Chen, Huayue Wu,* Jiang Cheng, Qiang Zhang, Bing Zuo, Weike Su, Jinchang Ding, One-pot synthesis of diaryl ketones from aldehydes via palladium-catalyzed reaction with aryl boronic acids, Tetrahedron Lett． 2008, 49, 1884–1888． SCI-TOP
　　50．Jiuxi Chen, Dengze Wu, Fei He, Miaochang Liu, Huayue Wu,* Jinchang Ding, Weike Su*, Gallium(III) triflate-catalyzed one-pot selective synthesis of 2,3-dihydro-quinazolin-4(1H)-ones and quinazolin-4(3H)-ones, Tetrahedron Lett． 2008, 49, 3814-3818． SCI-TOP
　　51．Xian Chen, Huayue Wu,* Rong Xu, Miaochang Liu, Jinchang Ding, Weike Su, Gallium Trichloride–promoted highly regioselective ring opening of epoxides with NH4SCN and NaN3 in water, Synth． Commun． 2008, 38, 1855–1865． SCI
　　52．Changfu Zhang, Jiuxi Chen, Xiaochun Yu, Xian Chen, Huayue Wu,* Jianping Yu, B2O3/Al2O3 as an efficient and recyclable catalyst for the synthesis of β-amino alcohols under solvent-free conditions, Synth． Commun． 2008, 38, 1875–1887． SCI
　　53．Fei He, Huayue Wu, Jiuxi Chen, Weike Su, Unexpectedly high activity of Zn(OTf)2∙6H2O in catalytic Friedel–Crafts acylation reaction, Synth． Commun． 2008, 38, 255–264． SCI
　　54．Jiuxi Chen, Miaochang Liu, Xiaoliang Yang, Jinchang Ding, Huayue Wu,* Indium(III)-catalyzed synthesis of N-substituted pyrroles under solvent-free conditions, J． Braz． Chem． Soc． 2008, 19, 877-883． SCI
　　55．Jiuxi Chen, Weike Su,* Huayue Wu,* Miaochang Liu, Can Jin, Eco-friendly synthesis of 2,3-dihydroquinazolin-4(1H)-ones in iionic liquids or ionic liquid–water without additional catalyst, Green Chem． 2007, 9, 972-975． SCI-TOP
　　56．Xian Chen, Changfu Zhang, Huayue Wu,* Xiaochun Yu, Weike Su*, Jiang Cheng, Solvent-free synthesis of β-hydroxy esters and β-amino esters by indium-mediated Reformatsky reaction, Synthesis 2007, 3233-3239． SCI-TOP
　　57．Changming Qin, Huayue Wu,* Jiang Cheng,* Xi’an Chen, Miaochang Liu, Weiwei Zhang, Weike Su, Jinchang Ding, The palladium-catalyzed addition of aryl- and heteroarylboronic acids to aldehydes, J． Org． Chem． 2007, 72, 4102-4107． SCI-TOP
　　58．Jiuxi Chen, Huayue Wu,* Weike Su, A facile synthesis of 2,3-dihydro-2-aryl-4(1H)-quinazolinones catalyzed by scandium(III) triflate, Chin． Chem． Lett． 2007, 18, 536–538． SCI-E
　　59．Xian Chen, Huayue Wu,* Weike Su, Rong Xu, Miaochang Liu, Jinchang Ding, Active metallic indium-mediated ring-opening of epoxides with diphenyl diselenides: a novel one-pot synthesis of β-hydroxy selenides in aqueous media, J． Chem． Res． 2007, 325-327． SCI
　　60．Weike Su,* Jiuxi Chen, Huayue Wu, Can Jin, A general and efficient method for the selective synthesis of α-hydroxy sulfides and β-hydroxy sulfoxides catalyzed by gallium(III) triflate, J． Org． Chem． 2007, 72, 4524-4527． SCI-TOP
　　61．Jiuxi Chen, Huayue Wu, Can Jin, Xingxian Zhang, Yuanyuan Xie, Weike Su,* Highly regioselective ring-opening of epoxides with thiophenols in ionic liquids without the use of any catalyst, Green Chem． 2006, 8, 330–332． SCI-TOP
　　62．Jiuxi Chen, Huayue Wu, Zhiguo Zheng, Can Jin, Xingxian Zhang, Weike Su,* An approach to the Paal–Knorr pyrroles synthesis catalyzed by Sc(OTf)3 under solvent-free conditions, Tetrahedron Lett． 2006, 47, 5383–5387． SCI-TOP

　　主要项目
　　1．《基于氢键活化环氧化物的不对称开环反应研究》国家自然科学基金( 21072153)，2011年1月-2013年12月，项目负责人
　　2．《绿色化学合成技术及应用创新团队》浙江省科技创新团队(2009R50002)，2010年7月-2012年7月，子课题负责人
　　3．《头孢、碳青霉烯系列原料药的绿色合成技术集成与示范》，国家“十一五”科技支撑计划(2007BAQ00155)，2007年8月-2010年12月，国家科技部，第二负责人
　　4．《华基化工股份有限公司全面合作协议》，横向委托，2009年3月-2012年3月，负责人
　　5．《头孢系列活性酯的绿色合成技术开发》，浙江省绿色化工重大专项（2006C11022），2006年6月，浙江省科学技术厅，子课题负责人
　　6．《纺织助剂十八烷基乙烯脲的清洁生产技术开发》浙江省科技计划项目（2005C31036），2005年01月，浙江省科学技术厅，项目负责人
　　7．《聚对芳撑乙炔类高聚物的合成、修饰及表征》，浙江省自然科学基金（Y405015），2006年01月，项目负责人
　　8．《医药中间体2-氯苯并咪唑的合成研究》，浙江省科技计划项目（2003C31026），2003年01月，浙江省科学技术厅，项目负责人
　　9．《吡咯酯的合成研究》，横向委托项目，2004年12月，项目负责人
　　10．《辣椒素微胶囊的研制及其在电线、电缆护套线防鼠咬应用研究》，横向委托项目，2004年12月，项目负责人
　　11．《炔草酯原药研制开发》，招标项目，2004年11月，项目负责人
　　12．《邻乙氧基苯酚的高效节能、连续化清洁生产工艺研发》，横向委托，2004年11月，项目负责人

　　专利
　　1．吴华悦，黄小波，吴登泽，苏为科“一种2-氯苯并咪唑的化学合成方法”发明专利，ZL200710172683．9（2007-12-21）已授权
　　2．吴华悦，吴登泽，黄小波，苏为科“一种2-羟基苯并咪唑的化学合成方法”发明专利，ZL200710172682．4（2007-12-21）已授权
　　3．吴华悦，陈久喜，苏为科，刘妙昌“一种喹唑啉酮类化合物的合成方法”发明专利，ZL200710156597．9（2007-11-9）已授权
　　4．吴华悦，何 飞，苏为科，陈久喜“一种黄酮类化合物的化学合成方法”发明专利，ZL200810060946．1（2008-04-08）已授权

　　学术获奖
　　1．浙江省科学技术奖三等奖，绿色化学技术及金属试剂在有机合成中的应用研究，2009年，排名第一
　　2．浙江省科学技术奖三等奖，含氮杂环及β-羟基类化合物的绿色合成研究，2010年，排名第四

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