姓名： 马新亮 性别：男 职称：教授

职务：Thomas Jefferson大学急诊医学部研究中心主任

招生院所：基础医学院招生类型：科学学位(博) 科学学位(硕)

招生专业：病理学与病理生理学(博) 病理学与病理生理学(硕)

研究方向名称：心血管疾病的研究

电子信箱：xinlm2000@163.com

社会任职

1. American Heart Association 成员

2. American Physiology Society 成员

3. Society for Academic Emergency Medicine 成员

4. Nitric Oxide Society 成员

5. American Diabetes Association 成员

6. National Institutes of Health 成员

7. 《Journal of Cardiothoracic-Renal Research》编委

8. 《American Journal of Physiology: Endocrinology and Metabolism》编委

9. 《Pathology and Laboratory Medicine International》编委

10. 《Diabetes Review Letters》编委

个人简历

1. 197609-197908:山西医学院 学士

2. 197909-198209:山西医学院 硕士

3. 198602-198807:第四军医大学 博士

4. 198910-199106:美国托马斯?杰佛逊大学生理学系 博士后

5. 199107-199307:美国托马斯?杰佛逊大学生理学系 实验室主任

6. 199307-199707:美国托马斯?杰佛逊大学医学院急诊医学部 助理教授

7. 199707-200207:美国托马斯?杰佛逊大学医学院急诊医学部 副教授

8. 200207- :美国托马斯?杰佛逊大学医学院急诊医学 教授

9. 201005- :首都医科大学生理与病理生理学系 教授

重要学术论文

1. Yu QJ, Gao F, Ma XL.Insulin says NO to cardiovascular disease. . Circ Res. 2011,89:516-524.SCI

2. Yu QJ, Gao F, Ma XL*..Insulin says NO to cardiovascular disease. Invited review article. . Cardiovasc Res. 2011,89:516-524.SCI

3. Cilenti L, Balakrishnan MP, Wang XL, Ambivero C, Sterlicchi M, Monte FD, Ma XL*, and Zervos AS. .Regulation of Abro1/KIAA0157 during myocardial infarction and cell death reveals a novel cardioprotective mechanism for Lys63-specific deubiquitination. . Journal of Molecular and Cellular Cardiology. 2011,50(4):652-661.SCI

4. Yuan Y, Gao E, Wang Y, Wang XL, Yi W, Lau WB, Wong W, Koch W, Ma X*..CTRPs, A novel therapeutic target against myocardial ischemia/reperfusion injury. . Circulation. 2010,122:A14133.SCI

5. Lau WB, Tao L, Wang YJ, Li R, MA XL.Systemic Adiponectin Malfunction as a Risk Factor for Cardiovascular Disease. Antioxidant & Redox Signaling. 2010,11:21.SCI

6. Yi W, Sun Y, Gao EH, Wei XF, Lau WB, Zheng QJ, Wang YJ, Yuan YX, Wang XL, Tao L, Li R, Kock WJ, Ma XL.Reduced Cardioprotective Action of Adiponectin in High Fat Diet Induced Type II Diabetic Mice and its Underlying Mechanisms. Antioxidant & Redox Signaling. 2010,11:21.SCI

7. 177. Chen G, Lai W, Liu F, Mao Q, Tu F, Wen J, Xiao H, Zhang JC, Zhu T, Chen B, HuZY, Li RM, Liang Z, Nie H, Yan H, Yang BX, Du Q, Huang WX, Jiang YW, Kwan AS, Song L, Wu CM, Xiang T, Xu HW, Lau WB, Song HB, Wen CB, Yao ZH, Zhang L, Zeng J, Dai YE, Lopez BL, Zheng JQ, Zhou J, Christopher TA, Ma XL, . The dragon strikes: Lessons from the Wenchuan earthquake. Anesth Analg. 2010,110:908-915.SCI

8. 173. Yuan YX, Jiao XY, Lau WB, Wang YJ, Christopher TA, Lopez BL, RamachandraRao SP, Tao L, Ma XL.Reduced vascular responsiveness to adiponectin in hyperlipidemic rats-mechanisms and significance. J Mol Cell Cardiol. 2010,49:508-515.SCI

9. Wang YJ, Lau WB, Gao EH, Tao L, Yuan YX, , Li R, Wang XL, Kock WJ, Ma XL*..Cardiomyocyte-Derived Adiponectin is Biologically Active in Protecting Against Myocardial Ischemia/Reperfusion Injury.. Am J Physiol Endocrinol Metab. 2010,298:E663-670.SCI

10. Yuan YX, Jiao XY, Lau WB, Wang YJ, Christopher TA, Lopez BL, RamachandraRao SP, Tao L, Ma XL*. .Thioredoxin glycation: A novel post-translational modification that inhibits its anti-oxidant and organ protective actions. . Free Rad Biol Med. 2010,19:332-338.SCI

11. Tao L, Wang YJ, Gao EH, Zhang HX, Yuan YX, Lau WB, Chan L, Koch WJ, Ma XL*. .Adiponectin: An Indispensable Molecule in Rosiglitazone Cardioprotection Following Myocardial Infarction.. Circ Res. 2010,106:409-417.SCI

12. Yan Z, Liang F, Guo L, Wang J, Wang XL, Cheng XL, Ma XL, Liu HR. .Myeloperoxidase increased cardiomyocyte protein nitration in mice subjected to nonlethal mechanical trauma. . Biochem Biophys Res Commun. 2010,393:531-535.SCI

13. Wang XL, Lau WB, Yuan YX, Wang YJ, Yi W, Christopher TA, Lopez BL, Liu HR, Ma XL*. .Methylglyoxal increases cardiomyocyte ischemia/reperfusion injury via glycative inhibition of thioredoxin activity.. Am J Physiol Endocrinol Metab. 2010,299:E207-214.SCI

14. Gao EH, Lei YH, Shang X, Huang ZM, Zuo L, Boucher M, Fan Q, Chuprun JK, Ma XL, Koch WJ. .A Novel and Efficient Model of Coronary Artery Ligation and Myocardial Infarction in the Mouse. Circ Res. 2010,107:1445-1453.SCI

15. Li R, Lau WB, Ma XL*..Adiponectin resistance and vascular dysfunction in the hyperlipidemic state. . Acta Pharmacologica Sinica. 2010,31(10):1258-1266.SCI

16. Lau WB, Tao L, Wang YJ, Li R, MA XL..Systemic Adiponectin Malfunction as a Risk Factor for Cardiovascular Disease. Antioxidant & Redox Signaling. 2010,11:21.SCI

17. Wang YJ, Gao EH, Tao L, Lau WB, Yuan YX, Goldstein BJ, Lopez BL, Christopher TA, Tian R, Koch W, Ma XL*. .AMPK Deficiency Enhances Myocardial Ischemia/Reperfusion Injury but has Minimal Effect on Adiponectin’s Anti-Oxidant/Anti-Nitrative Protection.. Circulation. 2009,119:835-844.SCI

18. Liu HR, Tao L, Gao EH, Qu Y, Lopez BL, Christopher TA, Koch W, Yue TL, Ma XL*..Rosiglitazone Inhibits Hypercholesterolemia-Induced Myeloperoxidase Upregulation -a Novel Mechanism for the Cardioprotective Effects of PPAR Agonists.. Cardiovasc Res. 2009,81:344-352.SCI

19. Ye MX, Wang YM, Ma XL, Pei JM..Rosiglitazone, not only potentially protects myocardium against complications of type 2 diabetes mellitus but also induces myocardium infarction: Possible mechanisms? . Bioscience Hypotheses. 2009,2:176-177.SCI

20. Wang YJ, Tao L, Yuan YX, Lau WB, Li R, Lopez BL, Christopher TA, Tian R, Ma XL*..Cardioprotective Effect of Adiponectin is Partially Mediated by its AMPK-Independent Anti-Nitrative Action.. Am J Physiol Endocrinol Metab . 2009,297:E384-391.SCI

21. Jiao XY, Gao EH, Yuan YX, Wang YJ, Lau WB, Koch W, Ma XL, Tao L..INO-4885, a Novel Peroxynitrite Decomposition Catalyst, Protects the Heart against Reperfusion Injury in Mice.. J Pharm Exp Ther. 2009,328:777-784.SCI

22. Cao Y, Tao L, Jiao XY, Lau WB, Yuan YX, Wang YJ, Christopher TA, Lopez BL, Chan L, Goldstein BJ, Ma XL*. .Endothelial Dysfunction in Adiponectin Deficiency and its Mechanisms Involved. . JMCC. 2009,46(3):413-419.SCI

23. Goldstein BJ, Scalia RG, Ma XL*..Protective vascular and myocardial effects of adiponectin.. Nat Clin Pract Cardiovasc Med. 2009,6:27-35.SCI

24. Li R, Wang WQ, Zhang HF, Yang XC, Fan Q, Christopher TA, Lopez BL, Tao L, Goldstein, BJ, Gao F, Ma XL*. .Adiponectin Improves Endothelial Function in Hyperlipidemic Rats by Reducing Oxidative/Nitrative Stress and Differential Regulation of eNOS/iNOS Activity. . Am J Physiol Endocrinol Metab . 2007,293:1703-1708.SCI

25. Wang XL, Liu HR, Tao L, Liang F, Yan L, Zhao RR, Lopez BL, Christopher TA, Ma XL*. .Role of iNOS-Derived Reactive Nitrogen Species and Resultant Nitrative Stress in Leukocytes-Induced Cardiomyocyte Apoptosis after Myocardial Ischemia/Reperfusion.. Apoptosis. 2007,12:1209-1217.SCI

26. Li SZ, Tao L, Jiao XY, Liu HR, Cao Y, Lopez BL, Luan RH, Christopher TA, Ma XL*..TNFα-Initiated Oxidative/Nitrative Stress Mediates Cardiomyocyte Apoptosis in Traumatic Animals.. Apoptosis. 2007,12:1795-1802.SCI

27. Zhang HX, Tao L, Gao EH, Jiao XY, Lopez BL, Christopher TA, Koch WJ, Ma XL*. .Nitrative Thioredoxin Inactivation as a Cause of Enhanced Myocardial Ischemia/Reperfusion Injury in the Aging Heart. Free Radical Biology and Medicine. 2007,43:39-47.SCI

28. Tao L, Gao ER, Jiao XY, Christopher TA, Lopez BL, Koch WJ, Chan L, Goldstein B, Ma XL*..Adiponectin Cardioprotection After Myocardial Ischemia/Reperfusion Involves the Reduction of Oxidative/Nitrative Stress . Circulation. 2007,115:1408-1416.SCI

主编或副主编的著作/译著

重要奖项

1. American Heart Association Research Excellence Award 200807

2. American College of Emergency Physician Established Investigator Award 200203

3. Who is Who in American, 56th Edition. 200109