姓名：王晓民性别：男职称：教授招生院所：基础医学院招生类型：科学学位(博)科学学位(硕)招生专业：神经生物学(博)神经生物学(硕)研究方向名称：神经系统退变性疾病电子信箱：xmwang@ccmu.edu.cn

社会任职

1.教育部神经变性病重点实验室主任

2.北京脑重大疾病重点实验室—省部共建国家重点实验室主任

3.中国生理学会理事长

4.《转化医学研究》杂志，总编

5.北京脑重大疾病研究院院长

个人简历

1.197802-198212:中国医科大学医疗系学习

2.198212-198908:大连医科大学病理生理教研室助教、硕士研究生、讲师

3.198909-199105:北京医科大学生理学系博士研究生

4.199106-199306:德国慕尼黑大学生理研究所博士研究生

5.199306-199812:北京医科大学生理学系副教授、教授

6.199901-200005:北京医科大学神经科学研究所、北京医科大学神经生物学系教授、副所长、副系主任

7.200005-200312:北京大学神经科学研究所、北京大学医学部神经生物学系教授、副所长、副系主任

8.200312-200512:首都医科大学基础医学院教授、院长、副校长

9.200808-:首都医科大学神经生物学系教授、系主任、副校长

重要学术论文

1.ZhengY,ZhangWJ,WangXM*..Triptolidewithpotentialmedicinalvaluefordiseasesofthecentralnervoussystem..CNSNeuroscience&Therapeutics.2013,19(2):76-82.SCI

2.WangY,WangX,LiR,YangZF,WangYZ,GongXL,WangXM*..ADNAmethyltransferaseinhibitor,5-aza-2'-deoxycytidine,exacerbatesneurotoxicityandupregulatesParkinson'sdisease-relatedgenesindopaminergicneurons..CNSNeuroscience&Therapeutics.2013,19(3):183-90.SCI

3.ZhanjunZhang,DantaoPeng,HaiyanZhu,Xiao-MinWang*.ExperimentalEvidenceofGinkgoBilobaExtractEGBasaNeuroprotectiveAgentinIschemiaStrokeRats.BrainResBull..2012,87(2-3):193-198.SCI

4.JunJia,YanYu,Jia-HuiDeng,NicolaRobinson,MarkBoveyYun-HuaCui,Hui-RongLiu,WeiDing,Huan-GanWu*,Xiao-MinWang*.AreviewofOmicsresearchinacupuncture:therelevanceandfutureprospectsforunderstandingthenatureofmeridiansandacupoints..JournalofEthnopharmacology.2012,140(3):594-603.SCI

5.CuiYQ,JiaYJ,ZhangT,ZhangQB,WangXM*..Fucoidanprotectsagainstlipopolysaccharide-inducedratneuronaldamageandinhibitstheproductionofproinflammatorymediatorsinprimarymicroglia..CNSNeuroscience&Therapeutics.2012,18(10):827-33.SCI

6.HuoLR,LiangJT,ZouJH,WangLY,LiQ,WangXM*..Possiblenovelrolesofpoly(rC)-bindingprotein1inSH-SY5Yneurocytes:ananalysisusingadynamicBayesiannetwork..NeuroscienceBulletin.2012,28(3):282-90.SCI

7.ZhengY,WangQ,XiaoB,LuQJ,WangYZ,WangXM*..Involvementofreceptortyrosinekinasetyro3inamyloidogenicAPPprocessingandb-amyloiddepositioninAlzheimer’sdiseasemodels..PLoSONE.2012,7(6)::e39035.SCI

8.YangJ,WangX,WangY,GuoZX,LuoDZ,JiaJ,WangXM*..Dopaminergicneuronalconversionfromadultratskeletalmuscle-derivedstemcellsinvitro..NeurochemicalResearch.2012,37(9)::1982-92.SCI

9.HuoLR,LiangXB,LiB,LiangJT,HeY,JiaYJ,JiaJ,GongXL,YuF,WangXM*..Thecorticalandstriatalgeneexpressionprofileof100Hzelectro-acupuncturetreatmentin6-hydroxydopamine-inducedParkinson’sdiseasemodel..Evidence-BasedComplementaryandAlternativeMedicine.2012,908439:doi:10.1155/2012/908439.SCI

10.SunZL,JiaJ,GongXL,JiaYJ,DengJH,WangX,WangXM*.Inhibitionofglutamateandacetylcholinereleaseinbehavioralimprovementinducedbyelectroacupunctureinparkinsonianrats..NeuroscienceLetters.2012,520(1):32-7.SCI

11.YuanHL,LiB,XuJ,WangY,HeY,ZhengY,WangXM*..Tenuigeninprotectsdopaminergicneuronsfrominflammation-mediateddamageinducedbythelipopolysaccharide..CNSNeuroscience&Therapeutics.2012,18(7)::584-90.SCI

12.ZhangLJ,XueYQ,YangC,YangWH,ChenL,ZhangQJ,QuTY,HuangS,ZhaoLR,WangXM*,DuanWM*..Humanalbuminprevents6-hydroxydopamine-inducedlossoftyrosinehydroxylaseininvitroandinvivo..PLoSONE.2012,7(7)::e41226.SCI

13.WangH,PanY,XueB,WangX,ZhaoF,JiaJ,LiangX,WangX*.Theantioxidativeeffectofelectro-acupunctureinamousemodelofParkinson'sdisease..PLoSOne..2011,6(5):e19790..SCI

14.JinxiaZhou,MelissaBroe,YueHuang,JohnP.Anderson,Wei-PingGai,ElizabethA.Milward,MichellePorritt,DavidHowells,AndrewJ.Hughes,XiaominWang*,GlendaM.Halliday*..Changesinthesolubilityandphosphorylationofa-synucleinoverthecourseofParkinson’sdisease..ActaNeuropathol.2011,121(6):695–704.SCI

15.XieY,ZhangYQ,ZhengZ,LiuAH,WangX,ZhuangP,LiYJ,WangXM*..ChangesinspeechcharactersofpatientswithParkinson’sdiseaseafterbilateralsubthalamicnucleusstimulation..JVoice.2011，25(6):751-8.2011,25(6):751-58.SCI

16.Yan-QiuCui,Li-JuanZhang,TingZhang,Ding-ZhenLuo,Yan-JunJia,Zi-XuanGuo,Quan-BinZhang,XuanWang,XiaominWang∗.InhibitoryEffectofFucoidanonNitricOxideProductioninLipopolysaccharide-activatedPrimaryMicroglia.ClinicalandExperimentalPharmacologyandPhysiology.2010,37:422–428.SCI

17.JunJia,BoLi,Zuo-LiSun,FenYu,XuanWang,andXiaominWang∗.Electro-acupunctureStimulationActsontheBasalGangliaOutputPathwaytoAmeliorateMotorImpairmentinParkinsonianModelRats.BehavNeurosci.2010,24:305-10.SCI

18.LiLu,FengqiaoLi,XiaominWang*.NoveltherapeuticagentsforParkinsondiseasethroughanti-inflammatoryandneuroprotectiveeffects.CNSNeurolDisordDrugTargets.2010,9:232-40.SCI

19.GuoZ,ShiF,ZhangL,ZhangH,YangJ,LiB,JiaJ,WangX,WangXM∗.CriticalroleofL-typevoltage-dependentCa2+channelsinneuralprogenitorcellproliferationinducedbyhypoxia..NeuroscienceLetters.2010,479:187–191.SCI

20.FengZhao,XiaotongFan,RichardGrondinRamseyEdwards,EricForman,JenniferMoorehead,GregGerhardt,XiaominWang*.Improvedmethodsforelectroacupunctureandelectromyographicrecordingsinnormalandparkinsonianrhesusmonkeys.JNeurosciMethods..2010,192:199-206.SCI

21.YanZheng,LijuanZhang,QingjunLu,XuanWang,FenYu,XiaominWang,*QingxianLu*.NGF-inducedTyro3andAxlfunctionassurvivalfactorsfordifferentiatingPC12cells..BiochemicalandBiophysicalResearchCommunications.2009,378:371–375.SCI

22.LiminLiu,BoLi,YongWang,JunJia,ZuoliSun,JinmingZhang,JiaheTian,XiaominWang*.EvaluationofnigrostriataldamageanditschangeoverweeksinaratmodelofParkinson'sdisease:smallanimalpositronemissiontomographystudieswith[11C]β-CFT.NuclearMedicineandBiology.2009,３６:941-947.SCI

23.YongWang,XuanWang,LiminLiu,XiaominWang∗.HDACinhibitortrichostatinA-inhibitedsurvivalofdopaminergicneuronalcells.NeuroscienceLetters.2009,４６７:212-216.SCI

24.JunJia,ZuoliSun,BoLi,XuanWang,XiaominWang*.Electro-acupuncturestimulationimprovesmotordisordersinParkinsonianrats.BehaviouralBrainResearch.2009,２０５:214–218.SCI

25.DingzhenLuo,QuanbinZhang,HaominWang,YanqiuCui,ZuoliSun,JianYang,YanZheng,JunJia,FenYu,XuanWang,XiaominWang*.Fucoidanprotectsagainstdopaminergicneurondeathinvivoandinvitro.EuropeanJournalofPharmacology.2009,６１７:33–40.SCI

26.TingZhang,JingHu,WeiDingandXiaominWang*.DoxorubicinAugmentsrAAV-2TransductioninRatNeuronalCells.NeurochemistryInternational.2009,５５:521-528.SCI

27.KairongLi,BingXue,YueWang,XuanWang,HaominWang,andXiaominWang*.Regionaldifferencesinandthemolecularbasisoftheregulationofthedevelopmentofembryonicdopaminergicneuronsbyneonatalastrocytes.JournalofMolecularNeuroscience.2009,37:288-300..SCI

28.XuanWang,Xi-BinLiang,Feng-QiaoLi,Hui-FangZhou,Xian-YuLiu,Jian-JunWang,Xiao-MinWang*.TherapeuticStrategiesforParkinson’sDisease:TheAncientMeetstheFuture—TraditionalChineseHerbalMedicine,Electroacupuncture,GeneTherapyandStemCells.NeurochemicalResearch.2008,33(10):1956-63.SCI

29.WangX,WuH,ZhangZ,LiuS,YangJ,ChenX,FanM,WangXM*.Effectsofinterleukin-6,leukemiainhibitoryfactor,andciliaryneurotrophicfactorontheproliferationanddifferentiationofadulthumanmyoblasts.CellMolecularNeurobiology.2008,28(1)::113-24.SCI

30.YM.Tian,X.Chen,DZ.Luo,XH.Zhang,H.Xue,LF.Zheng,N.Yang,XM.WANG*andJX.Zhu*.AlterationofdopaminergicmarkersingastrointestinaltractofdifferentrodentmodelsofParkinson’sdisease.Neuroscience.2008,153:634-644.SCI

31.YuntaoGong,BingXue,JianJiao,LimingJing,XiaominWang*..Triptolide,achineseherbalextract,inhibitscox-2expressionandPGE2releasebysuppressingtheactivityofnuclearfactor-κbandc-junnh2-terminalkinaseinmicrogliafollowinglipopolysaccharidestimulation.JournalofNeurochemstry.2008,107(3):779-788.SCI

32.JianJiao,BingXue,LeiZhang,YuntaoGong,KairongLi,HaominWang,LimingJing,JunxiaXie,XiaominWang*.Triptolideinhibitsamyloid-β1-42-inducedTNF-αandIL-1βproductioninculturedratmicroglia..JournalofNeuroimmunology.2008,205:32–36.SCI

33.BingXue;JianJiao;LeiZhang;Kai-RongLi;Yun-TaoGong;Jun-XiaXie;Xiao-MinWang*.TriptolideUpregulatesNGFSynthesisinRatAstrocyteCultures.NeurochemicalResearch.2007,32(7)::1113-9.SCI

34.JunJia,XiaominWang13.JunJia,XiaominWang*,HuaLi,SongHan,PengyuZu,JunfaLi.InvolvedinOxygen-GlucoseDeprivation-inducedNeuroprotectionviaNMDAReceptorsinHippocampalSlicesofMice.JournalofNeurosurgicalAnesthesiology.2007,19:18–24.SCI

35.Hui-FangZhou,Xian-YuLiu,Dong-BinNiu,Feng-QiaoLi,Qi-HuaHe,Xiao-MinWang*.Triptolideprotectsdopaminergicneuronsfrominflammation-mediateddamageinducedbylipopolysaccharideintranigralinjection.NeurobiologyofDisease.2005,18:441–449.SCI

36.JianjunWang,DongbinNiu,TingZhang,KunWang,BingXue,Xiao-MinWang*.Atetracycline-regulatableadeno-associatedvirusvectorfordouble-genetransfer..NeuroscceLetters.2005,378:106-110.SCI

37.XuanWang,XiaoxiaLi,KunWang,HuifangZhou,BingXue,LinsongLi,XiaominWang*.ForskolinCooperatingwithGrowthFactoronGenerationofDopaminergicNeuronsfromHumanFetalMesencephalicNeuralProgenitorCells.NeuroscienceLetters.2004,362:117-121.EI

38.KunWang,Jian-JunWang,YueWang,Qi-HuaHe,XuanWangandXiao-MinWang*.IntrastriatalAdministrationofEpidermalGrowthFactorandFibroblastGrowthFactor-2Up-RegulateProliferationandNeuronalDifferentiationofAdultNeuralProgenitorCellsDerivedFromtheStriatumInParkinsonianRats..NeuroscienceLetters.2004,364(3):154-158.SCI

39.Feng-QiaoLi,Xiu-ZhiLu,Xi-BinLiang,Hui-FangZhou,BingXue,Xian-YuLiu,Dong-BinNiu,Ji-ShengHan,Xiao-MinWang*.Triptolide,aChineseherbalextract,protectsdopaminergicneuronsfrominflammation-mediateddamagethroughinhibitionofmicroglialactivation.JNeuroimmunology.2004,148:24-31.SCI

40.Xi-BinLiang,YongLuo,Xian-YuLiu,JunLu,Feng-QiaoLi,QianWang,Xiao-MinWang*,Ji-ShengHan..Electro-acupuncturestimulationprotectsdopaminergicneuronsfrominflammation-mediateddamageinmedialforebrainbundletransectedrats..ExperimentalNeurology.2004,189:189－196.SCI

41.XuanWang,YanyanLu,HuanqingZhang,KunWang,QihuaHe,YueWang,XianyuLiu,LinsongLi,XiaominWang*.DistinctEfficacyofPre-differentiatedVersusIntactFetalMesencephalon-DerivedHumanNeuralProgenitorCellsinAlleviatingRatModelofParkinson’sDisease.InternationalJournalofDevelopmentalNeuroscience.2004,22(4):175-183.SCI

42.Xi-BinLiang,YongLuo,Xian-YuLiu,JunLu,Feng-QiaoLi,QianWang,Xiao-MinWang*,Ji-ShengHan.Electro-acupunctureimprovesbehaviorandupregulatesGDNFmRNAinMFBtransectedrats..NeuroReport.2003,14(8):1177-81.SCI

43.Hui-FangZhou,BingXue,Feng-QiaoLi,Xian-YuLiu,Qi-HuaHe,Xin-HongWangandXiao-MinWang*.Triptolide(PG490)inhibitsTNF-α,IL-1βandNOproductioninprimarymicroglia-enrichedcultures..NeuroReport.2003,14:1091-1095.SCI

44.Feng-QiaoLi,Xiao-XinCheng,Xi-BinLiang,Xin-HongWang,Bing*Xue,Qi-HuaHe,Xiao-MinWang*,Ji-ShengHan.Neurotrophicandneuroprotectiveeffectsoftripchlorolide,anextractofChineseherbTripterygiumWilfordiiHookF,ondopaminergicneurons..ExperimentalNeurology.2003,179:28－37.SCI

主编或副主编的著作/译著

1.《从分子到网络－细胞和分子神经科学导论》,主译,科学出版社,201006

2.《神经科学进展（四）》,主编,高等教育出版社,200606

3.《从分子到网络－细胞和分子神经科学导论》,主译,科学出版社,200603

4.《神经科学进展（三）》,主编,高等教育出版社,200406

5.《神经科学进展（二）》,主编,高等教育出版社,200309

6.《神经科学进展（一）》,主编,科学出版社,200202

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