中国海洋大学海洋生命学院导师：刘振辉 正文

　　刘振辉，男，博士，教授，硕士生导师。教育部新世纪优秀人才。现任生物系副主任。1971年生。
　　联系方式：0532-82032092; zhenhuiliu@ouc.edu.cn
　　
　　研究方向: 海洋生物功能基因研究；脂味觉的分子机制研究；肥胖模型的建立与调控研究；免疫机制与分子进化研究。

　　研究经历：2012-2013, 美国Utah State University博士后，从事味觉与肥胖调控机理研究；2007－2008，法国欧洲味觉研究中心博士后，德国汉堡大学分子神经研究所博士后，从事味觉的分子机理研究；2003—现在，中国海洋大学海洋生命学院讲师、副教授、教授，主要从事原索动物和鱼类的发育、免疫与进化研究。山东省“泰山学者”研究团队主力成员；2000－2003, 中国海洋大学海洋生物学专业，获博士学位；1997-2000，中国海洋大学水产养殖专业，获硕士学位。

　　研究课题：海洋“863”重点项目“海洋模式生物文昌鱼免疫防御的关键基因研究” （2008AA092603），132万元，2008－2012；教育部新世纪优秀人才项目“鱼类卵黄脂磷蛋白免疫新功能的分子机理研究”，50万元，2009－2011；留学回国启动基金，3万元，2010-2012；国家自然科学基金 “文昌鱼CD19类蛋白的鉴定及基因克隆与进化研究”（30500256），22万元，2006.1-2008.12；海洋“863” 子课题 “海洋重要动物免疫相关基因的研究与开发”（2005AA626012），109万元， 2005-2006。

　　奖励：山东省自然科学奖一等奖一项（第二位），2007年；教育部自然科学奖二等奖一项（第二位），2006年；国家海洋局海洋创新成果一等奖一项（第五位），2004年；山东省高等学校自然科学奖一等奖（第二位），2006年；青岛市自然科学一等奖（第二位），2005年；中国海洋大学优秀班主任和中国海洋大学“天泰”优秀教师奖，2006年。

　　论文：已发表论文50余篇，其中在SCI源期刊上发表论文近40篇:
　　1. Yanling Sun, Zhenhui Liu*, Shicui Zhang. Tissue distribution, developmental expression and up-regulation of p8 transcripts on stress in zebrafish. Fish & Shellfish Immunology, 2010, 28:549-554. (通讯作者) IF: 3.1;
　　2. Claire Fenech, Lila Patrikainen, Daniel S. Kerr, Sylvie Grall, Zhenhui Liu, Fabienne Laugerette, Bettina Malnic and Jean-Pierre Montmayeur. Ric-8A, a Gα protein guanine nucleotide exchange factor potentiates taste receptor signaling. Frontiers in Cellular Neuroscience, October 2009 | Volume 3 | Article 11 | 1. doi: 10.3389/neuro.03.011.2009. SCI.
　　3. Zhenhui Liu*, Yanping Xu, Ling Wu and Shicui Zhang. Evolution of galanin receptor genes: insights from the deuterostome genomes. Journal of Biomolecular Structure and Dynamics. 2010,28:1, 97-106. IF：5.0.
　　4. Zhenhui Liu*, Lei Li, Hongyan Li, Shicui Zhang, Guangdong Ji, Yanling Sun. EST analysis of the immune-relevant genes in Chinese amphioxus challenged with lipopolysaccharide. Fish & Shellfish Immunology 26 (2009) 843–849. IF: 3.1;
　　5. Zhenhui Liu*, Yanling Sun, Naiguo Liu, Ningning Fan, Shicui Zhang. Characterization, expression, and response to stress of p8 gene in amphioxus. Fish & Shellfish Immunology. 27 (2009) 407–413. IF: 3.1;
　　6. Jing LUAN, Zhenhui LIU, Shicui ZHANG, Hongyan LI, Chunxin FAN, Lei LI. Characterization, Evolution and Expression of the Calmodulin1 Genes from the Amphioxus Branchiostoma belcheri tsingtauense. Acta Biochimica et Biophysica Sinica. 2007, 39 (4), 255–264. (通讯作者)。IF: 1.0;
　　7. Zhenhui Liu, Shicui Zhang, Hongyan Li, Jing Luan, Yongjun Wang, Lei Wang and Jianhan Xiang. Characterization and expression profile of AmphiCD63 encoding a novel member of TM4SF proteins from amphioxus Branchiostoma belcheri tsingtauense. DNA Sequence.2005， 16(3):195-201. IF: 0.6;
　　8. Zhenhui Liu, Shicui Zhang, Mei Liu, Yongjun Wang, and Anlong Xu, Evolution and expression of the amphioxus AmphiHMGB gene encoding a HMG-box protein. COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY. 2004, 137:131-138. IF: 1.6;
　　9. Zhenhui Liu, Shicui Zhang, Mei Liu and Anlong Xu. Identification of the Ribosomal Protein S15a and L19 from the Amphioxus Branchiostoma belcheri tsingtauense. OPHELIA. 2004, 58(1): 23-27. IF: 0.9;
　　10. Zhenhui Liu, Jie Kong, Xiaowen Sun and Jingyao Deng. Application of RAPD technique for identification in three different stocks of Penaeus chinensis. Acta Oceanologica Sinica. 2003, 22(4): 629-634. IF: 0.4;
　　11. Zhenhui Liu, Zhang S., Yuan J., Sawant M.S., Wei J., and Xu A. Molecular Cloning and Phylogenetic Analysis of AmphiUbf80, a New Member of Ubiquitin Family from the Amphioxus Branchiostoma belcheri tsingtauense. Current Science 2002, 83, 50-53. IF: 0.6;
　　12. N Liu, S Zhang, Z. Liu. Characterization and expression of gamma-interferon-inducible lysosomal thiol reductase (GILT) gene in amphioxus Branchiostoma belcheri with implications for GILT in innate immune response. Mol Immunol. 2007 Apr;44(10):2631-7. IF 3.7.
　　13. C Fan, S Zhang, Z. Liu. Identification and expression of a novel class of glutathione-S-transferase from amphioxus Branchiostoma belcheri with implications to the origin of vertebrate liver. Int J Biochem Cell Biol. 2007;39(2):450-61. IF 4.0.
　　14. L Wang, S Zhang, Z. Liu. Characterization and expression of amphioxus ApoD gene encoding an archetype of vertebrate ApoD proteins. Cell Biol Int. 2007 Jan;31(1):74-81. IF 1.2.
　　15. Jinduo Yuan, Shicui Zhang, Zhenhui Liu, Zhidong Luan, and Gengxi Hu. Cloning and phylogenetic analysis of an amphioxus myogenic bHLH gene AmphiMDF. Biochemical and Biophysical Research Communications, 2003, 301: 960-967. IF 3.0.
　　16. M. Liu, S. Zhang, Z. Liu, and A. Xu. Characterization, organization and expression of AmphiLysC, an acidic c-type lysozyme gene in amphioxus Branchiostoma belcheri tsingtauense. Gene, 2006, 367: 110-117. IF 2.7.
　　17. He Y, Tang B, Zhang S, Liu Z, Zhao B, Chen L. Molecular and immunochemical demonstration of a novel member of Bf/C2 homolog in amphioxus Branchiostoma belcheri: implications for involvement of hepatic cecum in acute phase response.Fish Shellfish Immunol. 2008 Jun;24(6):768-78. IF 3.2.
　　18. Tian J, Zhang S, Liu Z, Zhuang Y, Wang Y, Jiang S. Characterization and tissue-specific expression of phosphatidylcholine transfer protein gene from amphioxus Branchiostoma belcheri.Cell Tissue Res. 2007 Oct;330(1):53-61. IF 2.6.
　　19. Zhao B, Zhang S, Wang Y, Liu Z, Kong D. Characterization and expression of p23 gene in the amphioxus Branchiostoma belcheri.Comp Biochem Physiol B Biochem Mol Biol. 2006 Sep;145(1):10-5. IF 1.6.
　　20. Wang Y，Zhang S，Liu Z. Characterization and Expression of AmphiCL Encoding Cathepsin L Proteinase from Amphioxus Branchiostoma belcheri tsingtauense. Marine Biotechnology 2005,7: 279-286. IF 1.5.
　　21. Li Z, Zhang S, Zhang J, Liu M, Liu Z. Vitellogenin is a cidal factor capable of killing bacteria via interaction with lipopolysaccharide and lipoteichoic acid. Mol Immunol. 2009 Oct;46(16):3232-9.
　　22. Li L, Zhang S, Fan C, Liu Z, Luan J. Verification and tissue-specific expression of nifU-like gene from the amphioxus Branchiostoma belcheri. DNA Seq. 2008 Feb;19(1):20-7.
　　23. Luan J, Zhang S, Liu Z, Fan C, Ji G, Li L. Characterization, evolution and tissue-specific expression of AmphiCalbin, a novel gene encoding EF-hand calcium-binding protein in amphioxus Branchiostoma belcheri. Acta Biochim Biophys Sin (Shanghai). 2007 Nov;39(11):891-900.
　　24. Tian J, Zhang S, Liu Z, Wang Y. Evolution and expression of gamma-aminobutyric acid type A receptor-associated protein from the amphioxus Branchiostomabelcheri. DNA Seq. 2008 Jun;19(3):319-25.
　　25. Wang Y, Zhang S, Liu Z, Li H, Wang L. Identification and expression of amphioxus beta-microseminoprotein (MSP)-like gene encoding an ancient and rapidly evolving protein in chordates. Comp Biochem Physiol B Biochem Mol Biol. 2005 Nov;142(3):251-7.
　　26. Liu L, Zhang S, Liu Z, Li H, Liu M, Wang Y, Ma L. Ribosomal proteins L34 and S29 of amphioxus Branchiostoma belcheri tsingtauense: cDNAs cloning and gene copy number. Acta Biochim Pol. 2005;52(4):857-62.
　　27. Wang Y, Zhang S, Liu Z, Li H, Wang L. Amphioxus allantoicase: molecular cloning, expression and enzymatic activity. Comp Biochem Physiol B Biochem Mol Biol. 2005 Jun;141(2):237-43.
　　28. Liu NG, Zhang SC, Liu ZH, Liang YJ, Xue JY. Identification and tissue-specific expression of amphioxus GM2 activator protein gene from amphioxus Branchiostoma belcheri. DNA Seq. 2006 Apr;17(2):122-8.
　　29. Xue JY, Zhang SC, Liu NG, Liu ZH. Verification, characterization and tissue-specific expression of UreG, a urease accessory protein gene, from the amphioxus Branchiostoma belcheri. Acta Biochim Biophys Sin (Shanghai). 2006 Aug;38(8):549-55.

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