浙江大学医学院导师：朱丽君 正文

　　姓名：朱丽君
　　性别：女
　　所在学院：医学院
　　职称：副教授

　　研究方向：
　　神经生物学，突触传递的细胞和分子机制

　　学历和研究经历：
　　毕业于浙江医科大学生物医学工程系，毕业后分配到浙江医科大学分子生物学实验室工作，2002 年成立神经生物学教研室后转入神经生物学教研室从事教学和科研工作，同年以同等学力考上博士研究生，2005年6月毕业，获博士学位。
　　2003年3月至2005年4月公派赴美国City of Hope National Medical Center从事访问学者研究工作，2006年11月至2007年2月赴香港科技大学生物化学系从事合作研究。
　　主要研究方向为离子型谷氨酸受体及其亚单位在中枢神经系统生理及病理过程中的作用。

　　近几年主要科研项目：
　　1．神经元信息感受重要蛋白质膜转运的结构基础、调控及功能研究 国家重点基础研究（973）2010CB912002, 2010.1-2014.12（学术骨干）
　　2．PICK1蛋白磷酸化位点的鉴定和磷酸化功能研究，浙江省自然科学基金 Y2090195 2010.1 – 2011.12 （负责人）
　　3．核糖核苷酸还原酶亚基特异性抗肿瘤药物设计与生物活性研究。浙江省科技计划项目，2008.1－2010.12(负责人)
　　4.白细胞介素-2参与海马突触传递和可塑性调节及其机制的研究, 国家自然科学基金项目, J20060472, 2007.1-2009.12 (负责人，已结题)

　　代表论文：
　　（1） Lijun Zhu, Bingsen Zhou, Xinhuan Chen et al. Inhibitory mechanisms of heterocyclic carboxaldehyde thiosemicabazones for two forms of human ribonucleotide reductase. Biochemical Pharmacology 2009;78:1178-1185.
　　（2） Shao Xin*, Lijun Zhu*, Yubin Wang et al. Threonine 82 at the PDZ Domain of PICK1 is Critical for AMPA Receptor Interaction and Localization, Neurochemistry International (accepted) (* co-first author)
　　（3） Yi Shen, ShuangShuang Liu, MinYe Zhan, Jianhong Luo, Lijun Zhu. Interleukin-2 enhances dendritic development and spinogenesis in cultured hippocampal neurons. Anatomical Record (accepted) .
　　（4） Yi Shen*, Li-Jun Zhu*, Shuang-Shuang Liu, Su-Ya Zhou and Jian-Hong Luo. Interleukin-2 inhibits NMDA receptor-mediated currents directly and may differentially affect subtypes. Biochem Biophys Res Commun. 2006 Dec 15;351(2):449-54. (* co-first author)
　　（5） Min Guan, Lijun Zhu, George Somlo, et al. Bortezomib therapeutic effect is associated with expression of FGFR3 in multiple myeloma cells. Anticancer Res. 2009 Jan;29(1):1-9.
　　（6） Lijun Zhu, George Somlo, Bingsen Zhou, et al. Fibroblast Growth Factor Receptor 3 inhibited by short-hairpin RNAs Leads to Apoptosis in Multiple Myeloma. Molecular Cancer Therapeutics 2005 May;4(5):787-98
　　（7） Lijun Zhu, Yun Yen, Jimin Shao, et al.Fibroblast Growth Factor Receptor 3 Up-regulates Vascular Endothelial Growth Factor Expression In L6 Cells. International Journal of pharmacology 2(3): 324-330, 2006 .
　　（8） Zhu Lijun, Chen Z, Zhang LS, Xu SJ, Xu AJ, Luo JH. Spatiotemporal changes of the N-methyl-D-aspartate receptor subunit levels in rats with pentylenetetrazole-induced seizures. Neurosci Lett. 2004 Feb 6;356(1):53-6.
　　（9） Jimin Shao, Bingsen Zhou, Lijun Zhu, Weihua Qiu, Yate-Ching Yuan, Bixin Xi, and Yun Yen. In vitro characterization of enzymatic properties and inhibition of the p53R2 subunit of human ribonucleotide reductase. Cancer Research 2004; 64: 1-6.
　　（10） Jimin Shao, Bingsen Zhou, Lijun Zhu, Angel J. Di Bilio, Leila Su, Yate-Ching Yuan, Shijun Ren, Eric J. Lien, Jennifer Shih, and Yun Yen. Determination of the potency and subunit-selectivity of ribonucleotide reductase inhibitors with a recombinant-holoenzyme-based in vitro assay. Biochemical Pharmacology 2005; 69: 627–634.
　　（11） Shao J, Zhou B, Di Bilio AJ, Zhu Lijun, Wang T, Qi C, Shih J, Yen Y. A Ferrous-Triapine complex mediates formation of reactive oxygen species that inactivate human ribonucleotide reductase.Mol Cancer Ther. 2006 Mar;5(3):586-92.
　　（12） Chung V, Zhou B, Liu X, Zhu Lijun, Boo LM, Nguyen HV, Ann DK, Song J, Chen Y, Yen Y. SUMOylation plays a role in gemcitabine- and bortezomib-induced cytotoxicity in human oropharyngeal carcinoma KB gemcitabine-resistant clone. Mol Cancer Ther. 2006 Mar;5(3):533-40.
　　（13） Xu SJ, Chen Z, Zhu Lijun, Shen HQ, Luo JH. Visual recognition memory is related to basic expression level of NMDA receptor NR1/NR2B subtype in hippocampus and striatum of rats. Acta Pharmacol Sin. 2005 Feb;26(2):177-80.
　　（14） Chen zhong, Li Weidong, Zhu Lijun, Shen YingJie, Wei Erqing. Effects of histidine, a precursor of histamine, on pentylenetetrazole-induced seizures in rats Acta pharmacol Sin 2002;23(4) 361-366.
　　国际会议论文：
　　1. Lijun Zhu，Xin Shao, Huang WH, Wang YB, Yan XY, Zhu J, Shen Y, Xia J, Luo JH. Phosphorylation of PICK1 T82 is important for its interaction with GluR2 subunit of AMPA receptor and the receptor membrane trafficking. 2009 American society for neuroscience annual meeting, 2009/10/17-21.
　　2. Lijun Zhu, George Somlo, Bingsen Zhou, Jimin Shao, Jennifer Shih, Jianhong Luo Yun Yen. shRNA-induced inhibition of Fibroblast Growth Factor Receptor 3 in t(4;14) translocated multiple myeloma cells. Porc Amer Assoc Cancer Res, volume 45,2004.
　　3. Lijun Zhu, George Somlo, Bingsen Zhou, Jimin Shao, Kevin Clarke, Alison Hughes, Jianhong Luo, Yun Yen. Function of wild type fibroblast growth factor receptor 3 and Y373C, K650E mutants in human lymphoma U937 cells. Porc Amer Assoc Cancer Res, Volume 46,2005.
　　4. Jimin Shao, Bingsen Zhou, Lijun Zhu et al., In vitro high throughput screening assay of novel inhibitors with reconstituted ribonucleotide reductase holoenzyme. Porc Amer Assoc Cancer Res, volume 45,2004.
　　5. Min Guan, Lijun Zhu, George Somlo, Alison Hughes et al., Expression of wild type or specific mutations of FGFR3 in multiple myeloma cells is associated with variable PS-341 therapeutic effects. 98th AACR Annual Meeting—Apr 14-18, 2007; Los Angeles, CA
　　6. Jimin Shao, Bingsen Zhou, Lijun Zhu et al., Characterization of the interacting mechanisms between triapine and the small subunits of human ribonucleotide reductase. Porc Amer Assoc Cancer Res, Volume 46,2005.
　　7. JianHong Luo, Yu Gen, Lijun Zhu, D Ding Alternations in NMDA receptor subunit protein expression in different regions of rat brain following permanent ischemia Soc. Neurosci. Abstr. 1999;29:59 2
　　荣誉和奖项：
　　NMDA受体亚单位组成及其在发育过程中的表达 获1999年度卫生部医药科技进步三等奖（排名第4）
　　参编教材：
　　网络生物信息数据库及相关软件的应用。医学分子细胞生物学--研究策略和技术原理。罗建红主编。校内研究生教材

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