浙江大学生命科学学院生物科学系导师：吴雪昌 正文

　　姓名：吴雪昌
　　性别：男
　　所在学院：生命科学学院
　　职称：教授

　　主要研究方向：
　　1．酿酒酵母（S.cerevisiae）抗逆与高产乙醇分子机制及适应逆境进化的机理研究；基因组结构变异与代谢工程等构建高效利用多种糖、抗逆高产乙醇的酵母工业菌株；大规模乙醇工业化生产节水节能减排高产，降低环境污染及生产成本的机制与技术集成研究。
　　2． 具药用与保健功能生物源活性化合物的筛选、结构鉴定、药理与生理功能研究；基因组水平挖掘发现新天然活性化合物及其生物合成基因（簇）、合成途径解析与优化研究。
　　3．工业微生物产量性状遗传与关键基因的结构、表达调控与高产菌株的构建研究。

　　近3年SCI论文、著作（*：Corresponding author）
　　1．Tao XL1, Zheng DQ1, Liu TZ, Wang PM, Zhao WP, Zhu MY, Jiang XH, Zhao YH, and Wu XC* (2012). A Novel Strategy to Construct Yeast Saccharomyces cerevisiae Strains for Very High Gravity Fermentation. PLoS One, 7(2) :e31235
　　2．Wang PM, Zheng DQ, Liu TZ, Tao XL, Feng MG, Min H, Jiang XH, and Wu XC* (2012). Optimization of very-high-gravity fermentation in industrial Saccharomyces cerevisiae by glycerol metabolic engineering and improved genome shuffling. Bioresour Technol. (accepted).
　　3．Wang PM, Wu XC*, Chi XQ, Li YD, Zheng DQ, Ding R, and Min H (2011). Development and application of RAPD-SCAR markers to identify intra-species hybrids of industrial Saccharomyces cerevisiae. World J Microbiol Biotechnol, 27(1): 185-188.
　　4．Zheng DQ, Wu XC*, Tao XL, Wang PM, Li P, Chi XQ, Li YD, Yan QF, and Zhao YH (2011). Screening and construction of Saccharomyces cerevisiae strains with improved multi-tolerance and bioethanol fermentation performance. Bioresour Technol, 102(3): 3020-3027.
　　5．Zheng DQ, Wu XC*, Wang PM, Chi XQ, Tao XL, Li P, Jiang XH, and Zhao YH (2011). Drug resistance marker-aided genome shuffling to improve acetic acid tolerance in Saccharomyces cerevisiae. J Ind Microbiol Biotechnol, 38: 415-422.
　　6．Wang PM, Zheng DQ, Ding R, Chi XQ, Tao XL, Min H, and Wu XC*（2011）. Improvement of ethanol production in Saccharomyces cerevisiae by hetero-expression of GAPN and FPS1 deletion. J Chem Technol Biotechnol, 86: 1205-1210.
　　7．Wu XC*, Chi XQ, Wang PM, Zheng DQ, Ding R, and Li YD (2010). The evolutionary rate variation among genes of HOG-signaling pathway in yeast genomes. Biol Direct, 5: 46.
　　8．Chao-Dong Qian, Xue-Chang Wu*, Yi Teng, Wen-Peng Zhao, Ou Li, Sheng-Guo Fang, Zhao-Hui Huang and Hai-Chun Gao (2012). Battacin (Octapeptin B5), a New Cyclic Lipopeptide Antibiotic from Paenibacillus tianmuensis Active against Multidrug-resistant Gram-negative Bacteria. Antimicrobial Agents and Chemotherapy, 56(3):1458-1465.
　　9．Xue-Chang Wu*, Chao-Dong Qian, Hai-Huan Fang, Yan-Ping Wen, Jian-Ying Zhou, Zha-Jun Zhan, Rui Ding, Ou Li, Haichun Gao* (2011). Paenimacrolidin, a novel macrolide antibiotic from Paenibacillus sp. F6-B70 active against methicillin-resistant Staphylococcus aureus. Microbial Biotechnology, 4(4): 491-502.
　　10．Yanping Wen, Xuechang Wu*, Yi Teng, Chaodong Qian, Zhajun Zhan, Yuhua Zhao, Ou Li (2011). Identification and analysis of the gene cluster involved in biosynthesis of paenibactin, a catecholate siderophore produced by Paenibacillus elgii B69. Environmental Microbiology. 13(10): 2726-2737.
　　11．Rui Ding, Yudong Li, Chaodong Qian and Xuechang Wu* (2011). Draft Genome Sequence of Paenibacillus elgii B69, a Strain with Broad Antimicrobial Activity. Journal of Bacteriology 193 (17): 4537.
　　12．Rui Ding, Xue-Chang Wu*, Chao-Dong Qian, Yi Teng, Ou Li, Zha-Jun Zhan and Yu-Hua Zhao (2011). Isolation and identification of lipopeptide antibiotics from Paenibacillus elgii B69 with inhibitory activity against methicillin-resistant Staphylococcus aureus. J Microbiol. 49(6): 942-949
　　13．Xuechang Wu*, Haihuan Fang, Chaodong Qian, Yanping Wen, Xiaobo Shen, Ou Li, Haichun Gao* (2011). Paenibacillus tianmuensis sp. nov., isolated from soil of Tianmu Mountain National Natural Reserve in Zhejiang, China. Int J Syst Evol Microbiol. 61:1133–1137
　　14．Liang Zhu, Xuechang Wu*, Ou Li, Yamin Chen, Chaodong Qian, Yi Teng, Xianglin Tao, Haichun Gao (2011). Cloning and knockout of phytoene desaturase gene in Sphingomonas elodea ATCC 31461 for economic recovery of gellan gum. Journal of Industrial Microbiology and Biotechnology. 38:1507–1513.
　　15．Xuechang Wu*, Yamin Chen, Yudong Li, Ou Li, Liang Zhu, Chaodong Qian, Xianglin Tao, Yi Teng (2010). Constitutive expression of Vitreoscilla hemoglobin in Sphingomonas paucimobilis to improve gellan gum production. Journal of Applied Microbiology. 110(2): 422-430
　　16．Xuechang Wu*, Ou Li, Yamin Chen, Liang Zhu, Chaodong Qian, Yi Teng, Xianglin Tao (2010). A carotenoid-free mutant strain of Sphingomonas paucimobilis ATCC 31461 for the commercial production of gellan. Carbohydrate Polymers. 84(3): 1201-1207
　　17．Xue-Chang Wu*, Xiao-Bo Shen, Rui Ding, Chao-Dong Qian, Hai-Huan Fang & Ou Li (2010). Isolationand partial characterization ofantibiotics produced by Paenibacillus elgii B69. FEMS Microbiol Lett 310:32-38.
　　18．XuechangWu*, Ping Li, Chaodong Qian, Ou Li, Yinyan Zhou (2009). Trimeric coiled-coil domain of human pulmonary surfactant protein D enhances zinc-binding ability and biologic activity of soluble TRAIL. Molecular Immunology. 46(11-12): 2381-2388.
　　19．Yan-Ping Wen, Xue-Chang Wu*, Chao-Dong Qian, Yu-Hua Zhao, Hai-Huan Fang, Ou Li (2009). Bacillus tianmuensis sp nov., isolated from soil in Tianmu Mountain national natural reserve, Hangzhou, China. FEMS Microbiology Letters. 296(1): 26-30.
　　20．Ping Li, Jian Ying Zhou, Yin Yan Zhou, Chao Dong Qian, Ou Li, Hang Min*, Xue Chang Wu* (2009). The Coiled-coil Neck Domain of Human Pulmonary Surfactant Protein D Drives Trimerization and Stabilization of Thioredoxin, a Heterologous Non-collagenous Protein. Protein and Peptide Letters 16(3): 306-311.
　　21．闵航，吴雪昌，吕镇梅，贾小明等 （2011） 《微生物学》，副主编，国家精品课程教材，浙江大学出版社.

　　国家发明专利：
　　1．吴雪昌. 一种抗肿瘤融合蛋白及其应用。 申请号：200810121475.0。
　　2．吴雪昌，钱朝东，李欧，方海环，周建英，白骅，杜加秋，林建秋. 一种多烯大环内酯类化合物及其制备与应用。申请号：CN200910153060。
　　3．钱朝东，李欧，沈小波，白骅，吴雪昌，杜加秋，林建秋. 一种多肽菌素及其制备与应用。申请号：201010268371。
　　4．钱朝东，李欧，丁锐，白骅，吴雪昌，杜加秋，林建秋. 一种广谱多肽菌素及其应用。 申请号:201010554973。
　　5．吴雪昌，吴荣明，李 欧，朱 亮，陈亚敏，钱朝东，陈梅. 黄色素生成缺陷鞘脂单胞菌及其在结冷胶生产中的应用。申请号：CN200910153005。
　　6．吴雪昌，朱 亮，李 欧. 少动鞘氨醇单胞菌的八氢番茄红素脱氢酶基因及其应用。申请号：201010506928.9。
　　7．吴雪昌，朱 亮，李 欧. 少动鞘氨醇单胞菌的crtZ基因、crtG基因及其应用。申请号：201110183602.1。
　　8．吴雪昌，朱 亮，李 欧. 少动鞘氨醇单胞菌的番茄红素环化酶基因及其应用。申请号：201110184745.4。
　　9．吴雪昌,郑道琼，陶香林，王品美，刘天喆. 一株适合浓醪发酵的酿酒酵母菌株及其应用。 申请号：201110293252.4。
　　10．吴雪昌,王品美，郑道琼，陶香林，刘天喆. 低甘油合成、高酒精耐性的工业酿酒酵母菌株及其应用。 申请号：201110293244.X。

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