厦门大学生物学系导师：韩爱东 正文

　　姓名：韩爱东　　
　　性别：男　　
　　职称：教授　
　　学院：生命科学学院
　　研究方向：通过结构生物学实验手段研究在细胞编程和重编程过程中，转录因子与其辅因子的结构与功能，通过结构生物学实验手段，揭示其表观遗传和转录调控分子机制
　　E-mail: ahan@xmu.edu.cn
　　
　　个人简介：
　　1999年获中国科学学院微生物所微生物学博士学位；1999-2006年科罗拉多州大学生化系博士后；2006-2007年南加州大学分子与计算生物系博士后。
　　1999, Ph.D., Institute of Microbiology, Chinese Academy of Sciences; 1999-2006, Postdoctoral follow, University of Colorado at Boulder; 2006-2007, Senior research associate, University of Southern

　　主要研究领域（Research Area）
　　转录是基因表达的关键步骤，而转录因子与特异的增强子结合并进一步形成调节复合体。这些转录因子之间及与DNA间的相互作用能够有效地编程和重编程细胞, 如用Oct4, Sox2, Nanog和Klf4可以将体细胞转换为多潜能干细胞技术（iPS）。我们主要通过结构生物学实验手段研究在细胞编程和重编程过程中，转录因子与其辅因子的结构与功能，通过结构生物学实验手段，揭示其表观遗传和转录调控分子机制。我们的研究与退行性疾病、组织再生和修复有着紧密的联系。
　　Transcription is a key step for gene expression regulation, which in turn globally programs or reprograms the cells. Transcription factors as well as cofactors are centered on the specific enhancer regions of genes to form high-order regulatory assemblies. The most, if not all, of these cofactors are histone modification enzymes that convey a variety of upstream signals to epigenetic marks. This process is best illustrated in the stem cell production induced by a set of ectopically expressed transcription factors, including Oct4, Sox2, Nanog and Klf4 that can convert somatic cells into induced pluropotent stem cells (iPS). Their activities are always associated with epigenetic modifications, for example histones acetylation by p300, CBP and PCAF. Our lab is taking a structural and functional approach to understand molecular mechanisms of the epigenetics and transcriptional regulation.

　　代表性论文（Selected Publications）
　　He, Ju; Ye, Jun; Cai, Yongfei; Riquelme, Cecilia; Liu, Jun O.; Liu, Xuedong; Han, Aidong; Chen, L. Structure of p300 bound to MEF2 on DNA reveals a mechanism of enhanceosome assembly (accepted)
　　Wu Y, Dey R, Han A, Jayathilaka N, Philips M, Ye J, Chen L. Structure of the MADS-box/MEF2 domain of MEF2 bound to DNA and its implication for myocardin recruitment. Journal of Molecular Biology, Mar 26;397(2):520-33, 2010
　　Guo L, Han A, Bates DL. Cao J, Chen L. Crystal structure of a conserved N-terminal domain of histone deacetylase 4 reveals functional insights into glutamine-rich domains. Proceedings of the National Academy of Sciences USA, 13;104: 4297-4302, 2007.
　　Wu Y, Borde M, Heissmeyer V, Feuerer M, Lapan AD, Stroud JC, Bates DL, Guo L, Han A, Ziegler SF, Mathis D, Benoist C, Chen L& Rao A. FOXP3 controls regulatory T cell function through cooperation with NFAT. Cell, 126: 375-387, 2006.
　　Stroud JC, Wu Y, Bates DL, Han A, Nowick K, Paabo S, Tong H, Chen L. Structure of the forkhead domain of FOXP2 bound to DNA. Structure, Jan;4(1):159-166, 2006.
　　Han A, He J, Wu Y, Liu JO, Chen L. Mechanism of recuitment of class II histone deacetylases by Myocyte enhancer factor-2. Journal of Molecular Biology, 7;345(1):91-102, 2005.
　　Han A, Pan F, Stroud JC, Youn HD, Liu JO, Chen L. Sequence-specific recruitment of transcriptional co-repressor Cabin1 by Myocyte Enhancer Factor-2. Nature, 422(6933): 730-734, 2003.
　　
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