厦门大学生物学系导师：丁凤 正文

　　姓名：丁凤
　　性别：女　　
　　职称：副教授　
　　学院：生命科学学院
　　研究方向：分子遗传学
　　Email: dingf@xmu.edu.cn

　　个人简历：
　　1993年获得清华大学生物科学与技术系学士学位。
　　1998年获得 美国匹兹堡大学生物科学系, HHMI , 博士学位。
　　1998～2002 美国匹兹堡大学 博士后， 2000-2002 兼职匹兹堡大学转基因小鼠实验中心技术总管。
　　2002-2008 美国斯坦福大学医学院遗传学系 博士后。
　　2009- 厦门大学生命科学学院 副教授。

　　1993 B.S., Tsinghua University. 1998 Ph.D., University of Pittsburgh, department of Biological Science and Howard Hughes Medical Institute. 1998-2002, postdoctoral fellow, University of Pittsburgh. 2000-2002 Technical director of Transgenic and Knock out mouse facility, University of Pittsburgh. 2002-2008 Postdoctoral fellow, Stanford University, School of Medicine, Department of Genetics. 2009- Associate professor, Xiamen University, School of Life Sciences.

　　主要研究方向 （Research area）
　　利用小鼠模型和生化方法来研究人类的疾病，并且籍此探究激素的调控、食欲和代谢的调节、基因铭记的机理（genomic imprinting）, 以及非蛋白编码（non-coding）RNA的功能。研究的重点是Prader-Willi Syndrome (PWS), 这是最常见的因遗传而引起的肥胖症。
非蛋白编码RNA Snord116 基因敲掉（Knock-out）小鼠是PWS的模型，我们发现它们呈现有严重的生长发育迟缓，运动技能的学习障碍，以及过度进食等症状, 并且，和PWS病人一样， Snord116-deletion 小鼠血液中有高浓度的“饥饿激素” ghrelin。

　　研究重点：
　　1．探究Snord116-deletion 小鼠过度进食的根源，及调控正常进食行为的机制.
　　（1） 通过阻断ghrelin信号通路，探索贪食症的治疗方法。
　　（2）建立荧光蛋白GFP标记系统来研究ghrelin 的合成与分泌的调控机制. 并以这一系统为平台，筛选调节激素分泌和调控食欲的新型药物。
　　2．利用生化方法，研究和Snord116形成络合物的未知RNA 和蛋白质。进一步研究这些对生长发育和进食行为的调控。
　　3． 利用iRNA library，系统性地筛查并发现调控PWS区域epigenetic silencing的关键因子.

　　Research Area:
　　We use mouse models and biochemical methods to study human genetic disease, and to gain insight into the regulatory mechanisms of gastrointestinal hormone secretion, appetite and metabolism control，and to develop effective therapeutic interventions for obesity and eating disorders.
Prader-Willi Syndrome (PWS) is the leading genetic cause of obesity. Non-coding RNA Snord116 deletion mouse model of PWS exhibits growth retardation, motor learning deficiency, hyperphagia, as well as greatly increased secretion of appetite-promoting peptide, ghrelin,
　　
　　Future research will focus on:
　　1. Study of ghrelin signaling pathway, and the development of GFP knock-in mice to investigate the control mechanism of ghrelin synthesis and secretion, as well as the abnormalities in PWS mouse models. We’ll utilize this platform to screen for potential drugs that regulate hormone production and appetite.
　　2. Biochemical study of the function of non-coding RNA Snord116．
　　3. Systematic screen for essential factors for epigenetic silencing of imprinted genes at PWS loci by RNAi technology.

　　Research Articles
　　Ding F, Li HH, Li J, Myers RM, Francke U. Neonatal Starvation Response and Developmental Changes in Gene Expression Revealed by Hypothalamic Gene Expression Profiling in Mice (Submitted)
　　Li H-H, Roy M, Kuscuoglu U, Spencer CM, Halm B, Harrison KC, Bayle JH, Splendore A, Ding F, Meltzer LA, Wright E，, Paylor R， Deisseroth K, Francke U. Induced Chromosome Deletions Cause 　　Hypersociability and Other Features of Williams-Beuren Syndrome in Mice (In press, EMBO Molecular Medicine)
　　Ding F, Li HH, Zhang S, Solomon NM, Camper SA, Francke U. SnoRNA Snord116 (Pwcr1/MBII-85) deletion causes growth retardation, motor learning deficiency, hyperphagia and elevated ghrelin levels in mouse model for Prader-Willi syndrome. PLoS ONE. 2008 Mar 5;3(3):e1709
　　Press release: http://med.stanford.edu/news_releases/2008/march/prader-willi.html
Cirio MC, Ratnam S, Ding F, Reinhart B, Navara C, Chaillet JR. Preimplantation
expression of the somatic form of Dnmt1 suggests a role in the inheritance of genomic imprinting. BMC Developmental Biology 2008, 8:9
　　Ding F, Prints Y, Dhar MS, Johnson DK, Garnacho-Montero C, Nicholls RD, Francke U. Lack of Pwcr1/MBII-85 snoRNA is critical for neonatal lethality in Prader-Willi syndrome mouse models. Mamm Genome. 2005 Jun;16(6):424-31.
　　Ding F, Patel C, Ratnam S, McCarrey JR, Chaillet JR. Conservation of Dnmt1o cytosine methyltransferase in the marsupial Monodelphis domestica. Genesis. 2003 Aug;36(4):209-13.
　　Ding F, Chaillet JR. In vivo stabilization of the Dnmt1 (cytosine-5)-methyltransferase protein. Proc Natl Acad Sci U S A. 2002 Nov 12;99(23):14861-6.
　　Ratnam S, Mertineit C, Ding F, Howell CY, Clarke HJ, Bestor TH, Chaillet JR, Trasler JM. Dynamics of Dnmt1 methyltransferase expression and intracellular localization during oogenesis and 　　preimplantation development. Dev Biol. 2002 May 15;245(2):304-14.
　　Howell CY, Bestor TH, Ding F, Latham KE, Mertineit C, Trasler JM, Chaillet JR.Genomic imprinting disrupted by a maternal effect mutation in the Dnmt1 gene.Cell. 2001 Mar 23;104(6):829-38.
　　Ding F and Grabowski PJ, Identification of a protein component of a mammalian tRNASec complex implicated in the decoding fo UGA as selenocysteine, RNA, 1999, 5, 1561-1569
　　Ding F, Hagan JP, Wang Z, and Grabowski PJ, Biochemical properties of a novel U2AF65 protein isoform generated by alternative RNA splicing, Biochemical and Biophysical Research Communications, 1996, 224, 675-683.
　　Gong Y, Ding F, Li F, and Zhao N, Phospholipase C induced membrane fusion, Acta Biophysica Sinica, 1996, 12, (1), 43-50.

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