华南农业大学生命科学学院导师:张玲华
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华南农业大学生命科学学院导师:张玲华 正文
[导师姓名]张玲华
[所属院校]
华南农业大学
[基本信息]
导师姓名:张玲华
性别:
人气指数:1403
所属院校:华南农业大学
所属院系:生命科学学院
职称:教授
导师类型:博导
招生专业:微生物学、生物化学与分子生物学、生物工程
研究领域:微生物及免疫学
[通讯方式]
电子邮件:lhzhang@scau.edu.cn
[个人简述]
张玲华博士、华南农业大学生命科学学院教授、广东省农业生物蛋白质功能与调控重点实验室PI。在Vaccine、MolecularImmunology、DevelopmentalandComparativeImmunology等相关邻域主流杂志发表研究论文发表22篇论文,SCI收录22篇,累积影响因子48.998,总他引次数118,4项发明专利授权。
[科研工作]
工作经历
2006/1-至今,华南农业大学,生命科学学院,教授
科研项目
获得国家基金,省攻关,省基金,市重点攻关项目等多项项目支助。
发表论文
(1)Yang,J.,Lu,Z.P.,Chen,J.W.,Chu,P.P.,Cheng,Q.M.,Liu,J.,Ming,F.P.,Huang,C.Y.,Xiao,A.J.,Cai,H.M.,Zhang,L.H.(张玲华)*.(2016)EffectofcooperationofchaperonesandgenedosageontheexpressionofporcinePGLYRP-1inPichiapastoris.AppliedMicrobiologyandBiotechnology,DOI10.1007/s00253-016-7372-4.(*通讯作者,2015SCIImpactfactor,3.811)
(2)Cai,H.M.,KuangZ.S.,HuangK.Y.,Shi,J.Q.,ZhaoX.J.,Chu,P.P.,Huang,C.Y.,Ming,F.P.,Xia,F.G.,Yang,J.,Zhang,L.H.(张玲华)*.(2014)CpGoligodeoxynucleotideprotectneonatalpigletsfromchallengewiththeenterotoxigenicE.coli,VeterinaryImmunologyandImmunopathology,161,66–76(*通讯作者2013SCIImpactfactor,1.782)
(3)Ming,F.P.,Yang,J.,Chu,P.P.,Ma,M.P.,Shi,J.Q.,Cai,H.M.,参与人,Li,H.Z.,Jiang,Z.G.,Wang,W.F.,Zhang,S.Q.,ZhangL.H.(张玲华)*.(2013)ImmunizationofAgedPigswithAttenuatedPseudorabiesVirusVaccineCombinedwithCpGOligodeoxynucleotideRestoresDefectiveTh1ImmuneResponses,PLOSONE,8(6),65536-65536(*通讯作者,2013SCIImpactfactor,4.092)
(4)Ma,M.P.,Wang,L.L.,Yang,J.,Cai,H.M.,Shi,J.Q.,Huang,Z.F.,Zhang,S.Q.,ZhangL.H.(张玲华)*.(2012)Age-relatedimpairedTh1responsestoPRVvaccineinvivoinagedpigs,MolecularImmunology,52,217-222(*通讯作者,2011SCIImpactfactor,2.897)
(5)Yang,J.,Mao,M.P.,HuangZ.F.,Zhang,S.Q.,Chen,S.F.,Li,H.Z.,Jiang,Z.G.,Cao,G.J.,Cao,D.,Wang,X.F.,ZhangL.H.(张玲华)*.(2012)InnatedefenceregulatorpeptidesynergizeswithCpGODNforenhancedinnateinstestinalimmuneresponsesinneonatepiglets.Int.Immunopharmacol.12(2),415–424(*通讯作者,2011SCIImpactfactor,2.325)
(6)Cao,D.,Li,H.Z.,Jiang,Z.G,Cheng,Q.,Yang,Z.H.,Xu,C.C.,Cao,G.J.,ZhangL.H.(张玲华)*.(2011)CpGoligodeoxynucleotidesynergizesinnatedefenseregulatorpeptideforenhancingthesystemicandmucosalimmuneresponsestopseudorabiesattenuatedvirusvaccineinpigletsinvivo.Int.Immunopharmacol.11,748–754(*通讯作者,2010SCIImpactfactor,2.325)
(7)Cao,D.,Li,H.Z.,Jiang,Z.G,Xu,C.C.,Cheng,Q.,Yang,Z.H.,Cao,G.J.,ZhangL.H.(张玲华)*.(2010)SyntheticinnatedefenceregulatorpeptideenhancesinvivoimmunostimulatoryeffectsofCpG-ODNinnewbornpiglets.Vaccine.28,6006–6013.(*通讯作者,2009SCIImpactfactor,3.616)
(8)Cheng,Q.,Xu,C.C.,ZhangL.H.(张玲华)*,Li,J.Q.,Cao,T.,Zhang,M.R.(2010)AdministeredCpGOligodeoxynucleotideInducesmRNAexpressionofCXCandCCChemokinesattheIntestinalMucosaandPBMCsinPiglets.Int.Immunopharmacol.10,611-618(*通讯作者,2009SCIImpactfactor,2.214)
(9)Cheng,Q.,Jiang,Z.G.,Xu,C.C.,Li,H.Z.,Cao,D.,Yang,Z.H.,Cao,G.J.,ZhangL.H.(张玲华)*(2010)CpGoligodeoxynucleotidepromotesprotectiveimmunityintheentericmucosaandsuppressesenterotoxigenicE.coliintheweaningpiglets.Int.Immunopharmacol.10,1249–1260(*通讯作者,2009SCIImpactfactor,2.214)
(10)ZhangL.H.(张玲华)*,Tian,X.S.,Zhou,F.Z.(2008a)Invivooraladministrationeffectsofvariousoligodeoxynucleotidescontainingsyntheticimmunostimulatorymotifsintheimmuneresponsetopseudorabiesattenuatedvirusvaccineinnewbornpiglets.Vaccine.26,224-233.(*通讯作者,2007SCIImpactfactor,3.377)
(11)ZhangL.H.(张玲华)*,Zhang,M.R.,Li,J.Q.,Cao,T.,Tian,X.S.,Zhou,F.Z.(2008b)Enhancementofmucosalimmuneresponsesbyintranasalco-deliveryofNewcastlediseasevaccineplusCpGoligonucleotideinSPFchickensinvivo.ResearchinVeterinaryScience.85,495–502.(2007SCIImpactfactor,1.274)
(12)ZhangL.H.(张玲华)*,Tian,X.S.,Zhou,F.Z.(2007a)InvivoimmunostimulatoryeffectsofCpGODNinnewbornpiglets.MolecularImmunology.44,1238–1244.(*通讯作者,2006SCIImpactfactor,4.768)
(13)ZhangL.H.(张玲华)*,Tian,X.S.,Zhou,F.Z.(2007b)Invivoeffectsofoligodeoxynucleotidescontainingsyntheticimmunostimulatorymotifsintheimmuneresponsetoswinestreptococcicsepticemiavaccineinweanedpiglets.MolecularImmunology.44,1141–1149.(*通讯作者,2006SCIImpactfactor,4.768)
(14)ZhangL.H.(张玲华)*,Tian,X.S.,Zhou,F.Z.(2007c)Vaccinationwithporcinereproductiveandrespiratorysyndromekilledvirusvaccineandimmunostimulatoryoligodeoxynucleotidesinducesspecificimmunityinpiglets.Vaccine.25,1735–1742.(*通讯作者,2006SCIImpactfactor,3.159)
(15)ZhangL.H.(张玲华)*,Tian,X.S.,Zhou,F.Z.(2007d)VaccinationwithNewcastlediseasevaccineandCpGoligodeoxynucleotidesinducesspecificimmunityandprotectionagainstNewcastlediseasevirusinSPFchicken.VeterinaryImmunologyandImmunopathology.115,216–222.(*通讯作者,2006SCIImpactfactor,1.994)
(16)ZhangL.H.(张玲华)*,Tian,X.S.,Zhou,F.Z.(2007e)IntranasaladministrationofCpGoligonucleotidesinducesmucosalandsystemicType1immuneresponsesandadjuvantactivitytoporcinereproductiveandrespiratorysyndromekilledvirusvaccineinpigletsinvivo.InternationalImmunopharmacology.7(13),1732–1740.(*通讯作者,2006SCIImpactfactor,2.157)
(17)ZhangL.H.(张玲华)*,Tian,X.S.,Zhou,F.Z.(2007f)CpGoligodeoxynucleotidesaugmenttheimmuneresponsesofpigletstoswinePasteurellamultocidalivingvaccineinvivo.ResearchinVeterinaryScience.83(2),171-181.(2006SCIImpactfactor,1.258)
(18)ZhangL.H.(张玲华)*,Guo,Y.,Tian,X.S.,Zhou,F.Z.(2006a)Co-administrationofporcine-specificCpGoligodeoxynucleotideenhancestheimmuneresponsestopseudorabiesattenuatedvirusvaccineinnewbornpigletsinvivo.DevelopmentalandComparativeImmunology.30(6),589-596.(*通讯作者,2005SCIImpactfactor,3.261)
(19)ZhangL.H.(张玲华)*,Tian,X.S.,Guo,Y.,Zhou,F.Z.(2006b)EffectsofCpGODNonCD4+andCD8+Tsubpopulationsintheimmuneresponsetoporcinereproductiveandrespiratorysyndromekilledvirusvaccine.Vaccine.24(11),1874-1879.(*通讯作者,2005SCIImpactfactor,2.822)
(20)ZhangL.H.(张玲华)*,Tian,X.S.,Zhou,F.Z.(2006c)TheefficacyofCpGoligodinucleotides,incombinationwithconventionaladjuvants,asimmunologicaladjuvantstoswinestreptococcicsepticemiavaccineinpigletsinvivo.InternationalImmunopharmacology.6(8),1267-1276.(*通讯作者,2005SCIImpactfactor,2.008)
(21)ZhangL.H.(张玲华)*,Tian,X.S.,Zhou,F.Z.(2006d)Invivoeffectsofoligodeoxynucleotidescontainingsyntheticimmunostimulatorymotifsinweanedpiglets.InternationalImmunopharmacology.6(10),1623-1631.(*通讯作者,2005SCIImpactfactor,2.008)
(22)ZhangL.H.(张玲华)*,Guo,Y.,Tian,X.S.,Zhou,F.Z.(2006e)CpGoligodinucleotidesinducestronghumoralandcellularresponsestoswinestreptococcicsepticemiavaccineinpigletsinvivo.InternationalImmunopharmacology.6(3),342-350.(*通讯作者,2005SCIImpactfactor,2.008)
(23)ZhangL.H.(张玲华)*,Tian,X.S.,Guo,Y.,Zhou,F.Z.(2006f)Theeffectoftransgenicexpressionofporcineinterleukin-6geneandCpGsequencesonimmuneresponsesofthenewbornpigletsinoculatedwithpseudorabiesattenuatedvaccine.ResearchinVeterinaryScience.80,281-286.(2005SCIImpactfactor,1.106)
科研创新
(1)张玲华,田兴山,邝哲师,陈薇,李健雄,有益微生物制剂稳定化预处理工艺,2006.12,中国,ZL200310117512.8
(2)邝哲师,田兴山,张玲华,陈薇,李健雄,“有益微生物制剂稳定化后处理工艺”,2006.8,中国,ZL200310117511.3
(3)邝哲师,张玲华,徐志宏,“一种微生物转化菠萝渣为生物饲料的制备方法”,2008.1,中国,ZL200610033024.2
(4)张玲华,李华周,姜增固。“一种高效CpG制剂及其制备方法和应用”,2014.6,中国,ZL201210090979.7
(5)张玲华,明飞平,邝哲师,黄魁英,叶明强,赵祥杰,杨军,夏枫耿,赵培静,黄乐天、蓝碧锋、曹丁。“一种利用氧载体促进毕赤酵母高密度发酵的方法”,专利号:201310271420.9
(6)张玲华,邝哲师,蔡海明,赵祥杰,楚品品,叶明强,“一种高效提高枯草芽孢杆菌出芽率的方法”,专利号:201410162370.5
(7)张玲华,蔡海明,马苗鹏,周洁安,“一种高效抗炎性PBODN序列及其应用”,专利号:20151043403.5
(8)张玲华,马苗鹏,杨军,“一种嗜酸乳酸杆菌与醋酸杆菌混合发酵的方法”,专利号:201510335715.7
(9)江学斌,张玲华,胡位荣,马苗鹏,黄瀚威,“一种高效降低水体COD沼泽红假单胞菌的培养基”专利号:201610026084.5
[教育背景]
2007/9-2009/7,华南理工大学,发酵工程,博士,
1996/9-1999/7,华南理工大学,发酵工程,硕士,
1992/9-1996/7,华南理工大学,生物化工,学士
华南农业大学
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