姓名：石桂秀
性别：男
职称：教授
学院：厦门市第一医院
研究方向：风湿病病机与治疗研究


个人简介：

石桂秀教授简介 石桂秀， 博士，教授/博导。1992年于苏州医学院获医学硕士学位。毕业后任大连大学医学院中山医院医师，主治医师，自1995年起任该院临床免疫科主任。2000底至2004年7月，于加拿大蒙特利尔大学医学中心(CHUM of University of Montreal) 师从Jiangping Wu教授，攻读免疫学博士学位，并于2004年获得博士学位。2004年8月至2007年1月于美国Trudeau研究院师从Frances E. Lund教授作博士后。2007年2月至8月于美国德克萨斯大学(University of Texas) El Paso分校任助理教授。2007年9月回国任四川大学华西医院风湿免疫科教授，博士生导师, 并被遴选为四川省卫生厅学术带头人，现任四川省免疫学会理事长，中国免疫学会常务理事，成都市医学会风湿病专委会主任委员，国家自然基金会审（终审）评委。2011年获“厦门双百”创新人才称号。并被聘为厦门大学医学院教授，厦门大学第一医院主任医师。同年被聘为福建中医药大学硕士/博士生导师。目前的研究方向： 1.免疫调控与免疫应答；2.自身免疫病的发病机制及治疗学研究。

在研科研项目：

1）、30830094/C080701 《Gaq对B细胞分化的调控及其与自身免疫病的关系》 国家自然科学基金重点项目。课题负责人，2009-2012。
2）、30972678/C080101 《Gq蛋白在T细胞死亡和功能中的作用及其作用机制研究》国家自然科学基金重点项目。课题负责人，2010-2012。

近期发表的论著目录：

1. Dashan Wang, Yan Li, Yugao Zhang, Yuan Liu and Guixiu Shi. (2011) High-throughput screening (HTS) in identification new ligands and drugable targets of G protein-coupled receptors (GPCRs) . Combinatorial Chemistry & High Throughput Screening. 15: 232-241
2. Wang, Y., Li, Y.，He, Y.，Sun, Y.，Sun, W.，Xie, Q.，Yin, G.，Du, Y.，Wang, L.，Shi, G. (2011) Expression of G protein alphaq Subunit is Decreased in Lymphocytes from Rheumatoid Arthritis Patients and is Correlated with Disease Activity. Scand J Immunol Sep 16. doi: 10.1111/j.1365-3083.2011.02635.x. [Epub ahead of print]
3. Ravi S. Misra, Guixiu Shi(并列第一), Miguel E. Moreno-Garcia, Anil Thankappan, Michael Tighe, Betty Mousseau, Kim Kusser, Shirly Becker-Herman, Kelly L. Hudkins, Robert Dunn, Marilyn R. Kehry, Thi-Sau Migone, Ann Marshak-Rothstein, Melvin Simono, Troy D. Randall, Charles E. Alpers, Denny Liggitt, David J. Rawlings, and Frances E. Lund （2010）Gαq-containing G proteins regulate B cell selection and survival and are required to prevent B cell–dependent autoimmunity. Journal of Experimental Medicine. 2010, July (epub ahead of print: doi: 10.1084/jem. 20092735) . (IF： 15.612 ).
4. Jun Ouyang, Duan-gai Wen, Caibin Fan, Jianquan Hou, Xueguang Zhang, Guixiu Shi ( 2010）Donor antigen loaded IKK2dn gene modified dendritic cells prolong allo-graft survival Scandinavian Journal ofIimmunology, 71（5）：336-344）
5. Ruixia Li, Gang Liu, Kai Wang, Yixin Liu, Qibing Xie, Yi Liu and Guixiu Shi. (2009) Splenectomy for thrombocytopenia associated with systemic lupus erythematosus in 11 Chinese patients. Rheumatology International 2009 Nov 3. [Epub ahead of print]
6. Guihua Zhu, Gang Liu, Yixin Liu, Qibing Xie, Guixiu Shi. (2009) Liver abnormalities in adult onset Still's disease: a retrospective study of 77 Chinese patients. J Clin Rheumatol. 2009 Sep;15(6):284-8
7. Guixiu Shi, Santiago Partida-Sánchez, Michael Tighe, Michael T. Borchers, Melvin I. Simon, and Frances E. Lund。 (2007) Identification of an alternative Gaq-dependent chemokine receptor signal transduction pathway in dendritic cells and granulocytes. Journal of Experimental Medicine. 204(11): 2705-2718. (IF： 15.612 ).
8. Guixiu Shi, Hongyu Luo, Xiaochun Wan, Theodora W. Salcedo, Jun Zhang, and Jiangping Wu. (2002) Mouse T cells receive costimulatory signals from LIGHT, a TNF family member. Blood. 100:3279. (IF: 10.370; 被引用: 33次)
9. Guixiu Shi, Yulian Wu, Jun Zhang and Jiangping Wu. (2003) Death Decoy Receptor DcR3/TR6 Inhibits in vitro and in vivo T-Cell Chemotaxis. Journal of immunology 171:3407 (IF: 6.387; 被引用: 12次)
10. Guixiu Shi, Jianning Mao, Guang Yu, Jun Zhang and Jiangping Wu. (2005) Tumor vaccine based on cell surface expression of DcR3/TR6. Journal of immunology 174: 4727
11. Santiago Partida-Sanchez, Andreas Gasser, Ralf Fliegert, Cornelia C. Siebrands, Werner Dammermann, Guixiu Shi, Betty J. Mousseau, Adriana Sumoza-Toledo, Harivadan Bhagat, Timothy F. Walseth, Andreas H. Guse and Frances E. Lund. (2007) Chemotaxis of Mouse Bone Marrow Neutrophils and Dendritic Cells Is Controlled by ADP-Ribose, the Major Product Generated by the CD38 Enzyme Reaction. Journal of Immunology, 179: 7827-7839.
12. Partida-Sanchez S, Nava-Rivero L, Shi G, and Lund FE. (2007). CD38: an ecto-enzyme at the crossroads of innate and adaptive immune responses. In: Crossroads between Innate and Adaptive Immunity. ADV EXP MED BIOL 590: 171-183
13. Guixiu Shi, Genevieve S. Young, Kim Kusser1, James B. Kirkland, Troy D.Randall1 and Frances E. Lund. (2006) Increased sensitivity of CD38 deficient islet cells to DNA damage: Role for NAD and PARP-1. Molecular Medicine 12: s23 (IF: 3.349)
14. Santiago Partida-Sanchez, Andreas Gasser, Ralf Fliegert, Adriana Sumoza-Toledo1, Harivadan Bhagat, Guixiu Shi, Timothy F Walseth4, Andreas H Guse3 andFrances E Lund. (2006) CD38 enzymatic products cADPR and ADPR control Ca2+ influx and leukocyte chemotaxis through TRPM2 cation channels. Molecular Medicine 12: s19. (IF: 3.349)
15. Yulian Wu, Bing Han, Hongyu Luo, Guixiu Shi, Jiangping Wu. (2004) Dipeptide Boronic Acid, a Novel Proteasome Inhibitor, Prevents Islet-Allograft Rejection. Transplantation. 78(3): 360.
16. Xiaochun Wan, Guixiu Shi, Mark Semenuk , Jun Zhang, Jiangping. (2003) DcR3/TR6 Modulates immune cell interactions.Journal of Cellular Biochemistry. 89(3): 603.
17. Xiaochun Wan, Jun Zhang, Hongyu Luo, Guixiu Shi, Elena Kapnik, Sunghee Kim, Palanisamy Kanakaraj and Jiangping Wu. (2002) A TNF family member reversely costimulatory signals in to human T cells. Journal of Immunology 169(12): 6813-21. 。


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